{"id":"iptp-sulphadoxine-pyrimethamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Folate deficiency"},{"rate":null,"effect":"Stevens-Johnson syndrome (rare)"}]},"_chembl":{"chemblId":"CHEMBL36","moleculeType":"Small molecule","molecularWeight":"248.72"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug combination works synergistically: pyrimethamine inhibits dihydrofolate reductase while sulphadoxine inhibits dihydropteroate synthase, both enzymes critical for parasite folate metabolism. This dual inhibition prevents DNA synthesis and replication in malaria parasites. IPTp (Intermittent Preventive Treatment in pregnancy) uses this combination as chemoprophylaxis to prevent malaria infection during pregnancy.","oneSentence":"Sulphadoxine-pyrimethamine is an antimalarial combination that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in Plasmodium parasites.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:17:02.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prevention in pregnant women (Intermittent Preventive Treatment in pregnancy)"},{"name":"Malaria treatment and chemoprophylaxis"}]},"trialDetails":[{"nctId":"NCT04336189","phase":"PHASE3","title":"Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda","status":"COMPLETED","sponsor":"Grant Dorsey, M.D, Ph.D.","startDate":"2020-12-28","conditions":"Malaria","enrollment":2757},{"nctId":"NCT05471544","phase":"PHASE3","title":"Effectiveness, Feasibility and 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Awolowo University","startDate":"2020-08-10","conditions":"Pregnancy Malaria","enrollment":288},{"nctId":"NCT01669941","phase":"PHASE4","title":"Efficacy of Intermittent Screening and Treatment or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya","status":"COMPLETED","sponsor":"Kenya Medical Research Institute","startDate":"2012-08","conditions":"Pregnancy, Malaria","enrollment":1546},{"nctId":"NCT01443130","phase":"PHASE3","title":"Chloroquine for Malaria in Pregnancy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2012-02","conditions":"Malaria","enrollment":900},{"nctId":"NCT00432367","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-02","conditions":"Malaria, Anaemia, Pregnancy","enrollment":3333},{"nctId":"NCT02575755","phase":"PHASE4","title":"A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women","status":"UNKNOWN","sponsor":"Papua New Guinea Institute of Medical Research","startDate":"2012-10","conditions":"Pregnancy, Infections, Plasmodia, Drug Kinetics","enrollment":150},{"nctId":"NCT01103063","phase":"PHASE3","title":"Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa","status":"TERMINATED","sponsor":"Pfizer","startDate":"2010-10","conditions":"Intermittent Preventive Treatment In Pregnancy (IPTp)","enrollment":2891},{"nctId":"NCT01084213","phase":"PHASE4","title":"Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2010-06","conditions":"Malaria, Pregnancy, Anaemia","enrollment":5354},{"nctId":"NCT00811421","phase":"NA","title":"Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2009-09","conditions":"Pregnancy, Malaria, HIV Infections","enrollment":5820},{"nctId":"NCT01132248","phase":"PHASE2","title":"Activity of Mefloquine Against Urinary Schistosomiasis","status":"COMPLETED","sponsor":"Albert Schweitzer Hospital","startDate":"2010-05","conditions":"Urinary Schistosomiasis","enrollment":65},{"nctId":"NCT01636895","phase":"PHASE4","title":"Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria","status":"UNKNOWN","sponsor":"Malaria Consortium, UK","startDate":"2011-01","conditions":"Pregnancy Complications Parasitic","enrollment":600},{"nctId":"NCT00730366","phase":"PHASE3","title":"New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2004-03","conditions":"Malaria in Pregnancy","enrollment":2766},{"nctId":"NCT00964691","phase":"PHASE4","title":"A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands","status":"TERMINATED","sponsor":"Ministry of Health and Medical Services, Solomon Islands","startDate":"2009-08","conditions":"Malaria, Malaria in Pregnancy","enrollment":2504},{"nctId":"NCT00209781","phase":"NA","title":"IPTp Plus ITNs for Malaria Control in Pregnant Women","status":"UNKNOWN","sponsor":"Hospital Clinic of Barcelona","startDate":"2003-08","conditions":"Pregnancy","enrollment":1028}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Fansidar"],"phase":"phase_3","status":"active","brandName":"IPTp-sulphadoxine-pyrimethamine","genericName":"IPTp-sulphadoxine-pyrimethamine","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sulphadoxine-pyrimethamine is an antimalarial combination that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in Plasmodium parasites. Used for Malaria prevention in pregnant women (Intermittent Preventive Treatment in pregnancy), Malaria treatment and chemoprophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}