{"id":"iptp-sp","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1672558","moleculeType":"Small molecule","molecularWeight":"450.51"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IPTp-SP (Intermittent Preventive Therapy in pregnancy with Sulfadoxine-Pyrimethamine) works by administering therapeutic doses of the antimalarial drug sulfadoxine-pyrimethamine at scheduled intervals during pregnancy. Sulfadoxine-pyrimethamine inhibits dihydrofolate reductase in Plasmodium parasites, disrupting folate metabolism and preventing parasite replication. This approach reduces parasitemia, placental malaria, and associated adverse pregnancy outcomes including low birth weight and maternal anemia.","oneSentence":"IPTp-SP is a combination of intermittent preventive treatment using sulfadoxine-pyrimethamine to prevent malaria infection in pregnant women by inhibiting folate synthesis in the malaria parasite.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:08.601Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prevention in pregnant women (intermittent preventive therapy)"}]},"trialDetails":[{"nctId":"NCT04336189","phase":"PHASE3","title":"Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda","status":"COMPLETED","sponsor":"Grant Dorsey, M.D, Ph.D.","startDate":"2020-12-28","conditions":"Malaria","enrollment":2757},{"nctId":"NCT05471544","phase":"PHASE3","title":"Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-18","conditions":"Malaria","enrollment":3575},{"nctId":"NCT05478954","phase":"PHASE4","title":"Chemoprevention Efficacy Study in Burkina Faso","status":"UNKNOWN","sponsor":"Malaria Consortium","startDate":"2022-07-15","conditions":"Malaria","enrollment":800},{"nctId":"NCT03998839","phase":"","title":"TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study","status":"COMPLETED","sponsor":"Jhpiego","startDate":"2018-03-05","conditions":"Malaria in Pregnancy","enrollment":7200},{"nctId":"NCT04189744","phase":"PHASE3","title":"The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2019-12-15","conditions":"Pregnancy Malaria, Bacterial Vaginoses, Trichomonas 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Medicine","startDate":"2019-11-11","conditions":"Malaria in Pregnancy, Adherence, Treatment","enrollment":1600},{"nctId":"NCT04634695","phase":"","title":"Assessing to What Extent Dhps-431V Mutation May Influence the Protective Efficacy of IPTp-SP","status":"UNKNOWN","sponsor":"Obafemi Awolowo University","startDate":"2020-08-10","conditions":"Pregnancy Malaria","enrollment":288},{"nctId":"NCT01669941","phase":"PHASE4","title":"Efficacy of Intermittent Screening and Treatment or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya","status":"COMPLETED","sponsor":"Kenya Medical Research Institute","startDate":"2012-08","conditions":"Pregnancy, Malaria","enrollment":1546},{"nctId":"NCT01443130","phase":"PHASE3","title":"Chloroquine for Malaria in Pregnancy","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2012-02","conditions":"Malaria","enrollment":900},{"nctId":"NCT00432367","phase":"PHASE3","title":"Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2007-02","conditions":"Malaria, Anaemia, Pregnancy","enrollment":3333},{"nctId":"NCT01103063","phase":"PHASE3","title":"Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa","status":"TERMINATED","sponsor":"Pfizer","startDate":"2010-10","conditions":"Intermittent Preventive Treatment In Pregnancy (IPTp)","enrollment":2891},{"nctId":"NCT01084213","phase":"PHASE4","title":"Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2010-06","conditions":"Malaria, Pregnancy, Anaemia","enrollment":5354},{"nctId":"NCT00811421","phase":"NA","title":"Evaluation of Alternative Antimalarial Drugs for Malaria in Pregnancy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2009-09","conditions":"Pregnancy, Malaria, HIV Infections","enrollment":5820},{"nctId":"NCT01636895","phase":"PHASE4","title":"Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria","status":"UNKNOWN","sponsor":"Malaria Consortium, UK","startDate":"2011-01","conditions":"Pregnancy Complications Parasitic","enrollment":600},{"nctId":"NCT00730366","phase":"PHASE3","title":"New Approaches to Improve Coverage and Compliance of Antimalarial Treatment for Pregnant Women in Rural Africa","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2004-03","conditions":"Malaria in Pregnancy","enrollment":2766},{"nctId":"NCT00964691","phase":"PHASE4","title":"A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands","status":"TERMINATED","sponsor":"Ministry of Health and Medical Services, Solomon Islands","startDate":"2009-08","conditions":"Malaria, Malaria in Pregnancy","enrollment":2504}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Fansidar","SP"],"phase":"marketed","status":"active","brandName":"IPTp-SP","genericName":"IPTp-SP","companyName":"Kenya Medical Research Institute","companyId":"kenya-medical-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IPTp-SP is a combination of intermittent preventive treatment using sulfadoxine-pyrimethamine to prevent malaria infection in pregnant women by inhibiting folate synthesis in the malaria parasite. Used for Malaria prevention in pregnant women (intermittent preventive therapy).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}