{"id":"ipti","safety":{"commonSideEffects":[{"rate":null,"effect":"Adverse events dependent on specific antimalarial agent used"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IPTi involves giving therapeutic doses of antimalarial medications (typically sulfadoxine-pyrimethamine or other agents) to infants at defined intervals during their first year of life, regardless of malaria infection status. This approach maintains therapeutic drug levels in the blood during high-risk periods, preventing parasitemia and clinical malaria episodes. The strategy is designed to reduce the burden of malaria in infants in endemic areas while allowing some natural immunity development.","oneSentence":"IPTi (Intermittent Preventive Treatment in infants) is a malaria prevention strategy that administers antimalarial drugs at scheduled intervals to infants to prevent malaria infection and disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:04.153Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prevention in infants in endemic regions"},{"name":"Reduction of malaria morbidity and mortality in infants aged 2-11 months"}]},"trialDetails":[{"nctId":"NCT04235816","phase":"PHASE3","title":"Improving Care Through Azithromycin Research for Infants in Africa","status":"ACTIVE_NOT_RECRUITING","sponsor":"Barcelona Institute for Global Health","startDate":"2021-03-15","conditions":"Child Mortality","enrollment":20560},{"nctId":"NCT05085340","phase":"","title":"MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention","status":"COMPLETED","sponsor":"Barcelona Institute for Global Health","startDate":"2022-02-14","conditions":"Malaria","enrollment":94252},{"nctId":"NCT06173206","phase":"PHASE3","title":"Parasite Clearance and Protection from Infection (PCPI) in Cameroon","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-06-10","conditions":"Malaria","enrollment":902},{"nctId":"NCT05889052","phase":"","title":"Perennial Malaria Chemoprevention (PMC) in Cameroon","status":"ACTIVE_NOT_RECRUITING","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2023-07-19","conditions":"Anemia, Malaria","enrollment":2080},{"nctId":"NCT05856357","phase":"","title":"Perennial Malaria Chemoprevention (PMC) in Côte D'Ivoire","status":"ACTIVE_NOT_RECRUITING","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2023-08-11","conditions":"Malaria, Anemia","enrollment":1568},{"nctId":"NCT00158574","phase":"PHASE2, PHASE3","title":"Kilimanjaro IPTi Drug Options Trial","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2005-01","conditions":"Malaria","enrollment":2419},{"nctId":"NCT00425763","phase":"PHASE4","title":"Efficacy of Amodiaquine-artesunate in Children Aged 6-59 Months With Uncomplicated P. Falciparum Malaria","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2007-05","conditions":"Malaria","enrollment":110},{"nctId":"NCT00285662","phase":"NA","title":"Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants","status":"COMPLETED","sponsor":"Papua New Guinea Institute of Medical Research","startDate":"2006-06","conditions":"Malaria, Anemia","enrollment":1100},{"nctId":"NCT00206739","phase":"PHASE4","title":"Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infants","status":"COMPLETED","sponsor":"Bernhard Nocht Institute for Tropical Medicine","startDate":"2003-01","conditions":"Malaria, Anemia","enrollment":1070},{"nctId":"NCT00152204","phase":"PHASE3","title":"The Community Effectiveness of IPTi in Southern Tanzania","status":"UNKNOWN","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2005-03","conditions":"Malaria, Falciparum, Anemia","enrollment":13000},{"nctId":"NCT00209794","phase":"PHASE1, PHASE2","title":"IPTi in Mozambican Infants for Malaria Prevention","status":"UNKNOWN","sponsor":"Hospital Clinic of Barcelona","startDate":"2002-09","conditions":"Malaria","enrollment":1498},{"nctId":"NCT00168948","phase":"PHASE4","title":"Intermittent Antimalaria Treatment With SP in African Children","status":"UNKNOWN","sponsor":"Charite University, Berlin, Germany","startDate":"2003-03","conditions":"Malaria, Anemia","enrollment":1200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":122,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SP brand being used is Fansidar"],"phase":"phase_3","status":"active","brandName":"IPTi","genericName":"IPTi","companyName":"Swiss Tropical & Public Health Institute","companyId":"swiss-tropical-public-health-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IPTi (Intermittent Preventive Treatment in infants) is a malaria prevention strategy that administers antimalarial drugs at scheduled intervals to infants to prevent malaria infection and disease. Used for Malaria prevention in infants in endemic regions, Reduction of malaria morbidity and mortality in infants aged 2-11 months.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}