{"id":"iproniazid","rwe":[],"tags":[{"label":"Monoamine Oxidase Inhibitors","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Amine oxidase [flavin-containing] A","category":"target"},{"label":"MAOA","category":"gene"},{"label":"MAOB","category":"gene"},{"label":"N06AF05","category":"atc"},{"label":"Active","category":"status"},{"label":"Depressive disorder","category":"indication"},{"label":"Antidepressive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Monoamine Oxidase Inhibitors","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"}],"phase":"phase_2","safety":{"drugInteractions":[{"url":"/drug/alpha/beta-agonists","drug":"Alpha/Beta Agonists","action":"Use caution","effect":"MAO Inhibitors may enhance the hypertensive effect of Alpha/Beta-Agonists","source":"DrugCentral","drugSlug":"alpha/beta-agonists"},{"url":"/drug/amphetamines","drug":"Amphetamines","action":"Use caution","effect":"MAO Inhibitors may enhance the hypertensive effect of amphetamines","source":"DrugCentral","drugSlug":"amphetamines"},{"url":"/drug/indirectly-acting-sympathomimetic-amines","drug":"Indirectly Acting Sympathomimetic Amines","action":"Contraindicated","effect":"potentially fatal hypertensive crisis","source":"DrugCentral","drugSlug":"indirectly-acting-sympathomimetic-amines"},{"url":"/drug/selective-serotonin-reuptake-inhibitors","drug":"Selective Serotonin Reuptake Inhibitors","action":"Contraindicated","effect":"serotonin syndrome","source":"DrugCentral","drugSlug":"selective-serotonin-reuptake-inhibitors"},{"url":"/drug/serotonin/norepinephrine-reuptake-inhibitors","drug":"Serotonin/Norepinephrine Reuptake Inhibitors","action":"Contraindicated","effect":"serotonin syndrome","source":"DrugCentral","drugSlug":"serotonin/norepinephrine-reuptake-inhibitors"},{"url":"/drug/tricyclic-antidepressants","drug":"Tricyclic Antidepressants","action":"Contraindicated","effect":"very toxic and sometimes fatal reactions the serotonin syndrome or similar","source":"DrugCentral","drugSlug":"tricyclic-antidepressants"},{"url":"/drug/buspirone","drug":"buspirone","action":"Use caution","effect":"May increase blood pressure","source":"DrugCentral","drugSlug":"buspirone"},{"url":"/drug/dextromethorphan","drug":"dextromethorphan","action":"Contraindicated","effect":"fatal/non-fatal reactions","source":"DrugCentral","drugSlug":"dextromethorphan"},{"url":"/drug/levodopa","drug":"levodopa","action":"Contraindicated","effect":"life-threatening hypertensive reaction","source":"DrugCentral","drugSlug":"levodopa"},{"url":"/drug/methyldopa","drug":"methyldopa","action":"Use caution","effect":"hypertension may occur","source":"DrugCentral","drugSlug":"methyldopa"},{"url":"/drug/mirtazapine","drug":"mirtazapine","action":"Contraindicated","effect":"Label warning","source":"DrugCentral","drugSlug":"mirtazapine"},{"url":"/drug/pethidine","drug":"pethidine","action":"Use caution","effect":"potentially life-threatening reaction","source":"DrugCentral","drugSlug":"pethidine"},{"url":"/drug/phenylephrine","drug":"phenylephrine","action":"Contraindicated","effect":"potentially fatal hypertensive crisis","source":"DrugCentral","drugSlug":"phenylephrine"},{"url":"/drug/tramadol","drug":"tramadol","action":"Use caution","effect":"serotonin syndrome","source":"DrugCentral","drugSlug":"tramadol"},{"url":"/drug/tryptophan","drug":"tryptophan","action":"Contraindicated","effect":"severe behavioural and neurological signs of toxicity","source":"DrugCentral","drugSlug":"tryptophan"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"iprazid","offLabel":[],"synonyms":["marsilid","iproniazid phosphate","iproniazid","euphozid","iprazid","iprazide","iproniazide","iproniazide phosphate"],"timeline":[],"approvals":[],"brandName":"Iprazid","ecosystem":[{"indication":"Depressive disorder","otherDrugs":[{"name":"amitriptyline","slug":"amitriptyline","company":"Astrazeneca"},{"name":"amoxapine","slug":"amoxapine","company":"Lederle"},{"name":"bupropion","slug":"bupropion","company":"Glaxosmithkline"},{"name":"citalopram","slug":"citalopram","company":"Forest Labs"}],"globalPrevalence":280000000}],"mechanism":{"target":"Amine oxidase [flavin-containing] A","targets":[{"gene":"MAOA","source":"DrugCentral","target":"Amine oxidase [flavin-containing] A","protein":"Amine oxidase [flavin-containing] A"},{"gene":"MAOB","source":"DrugCentral","target":"Amine oxidase [flavin-containing] B","protein":"Amine oxidase [flavin-containing] B"}],"modality":"Small Molecule","drugClass":"Monoamine Oxidase Inhibitors","explanation":"Imagine your brain is a city with many roads. Neurotransmitters are like cars that travel along these roads, carrying messages between different parts of the brain. Iproniazid is like a traffic cop that stops the 'breakdown' of these cars, allowing more of them to be available to carry messages, which can help improve mood and reduce symptoms of depression.","oneSentence":"Iproniazid works by blocking the enzyme that breaks down certain neurotransmitters, allowing their levels to increase in the brain.","technicalDetail":"Iproniazid inhibits the activity of amine oxidase [flavin-containing] A (MAO-A), a flavin-containing enzyme responsible for the oxidative deamination of monoamines, such as serotonin, norepinephrine, and dopamine, thereby increasing their concentrations in the synaptic cleft and exerting its antidepressant effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1480","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IPRONIAZID","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:09:28.239527","biosimilars":[],"competitors":[{"drugName":"isocarboxazid","drugSlug":"isocarboxazid","fdaApproval":"1959-07-01","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"phenelzine","drugSlug":"phenelzine","fdaApproval":"1961-06-09","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tranylcypromine","drugSlug":"tranylcypromine","fdaApproval":"1961-02-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"iproniazid","indications":{"approved":[{"name":"Depressive disorder","source":"DrugCentral","snomedId":35489007,"regulator":"FDA","usPrevalence":21000000,"globalPrevalence":280000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"isocarboxazid","brandName":"isocarboxazid","genericName":"isocarboxazid","approvalYear":"1959","relationship":"same-class"},{"drugId":"phenelzine","brandName":"phenelzine","genericName":"phenelzine","approvalYear":"1961","relationship":"same-class"},{"drugId":"tranylcypromine","brandName":"tranylcypromine","genericName":"tranylcypromine","approvalYear":"1961","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167316","NDDF":"005260","UNII":"D892HFI3XA","CHEBI":"CHEBI:5958","INN_ID":"19","RXNORM":"353560","UMLSCUI":"C0022059","ChEMBL_ID":"CHEMBL92401","KEGG_DRUG":"D02579","DRUGBANK_ID":"DB04818","PUBCHEM_CID":"3748","SNOMEDCT_US":"1217172005","SECONDARY_CAS_RN":"305-33-9","MESH_DESCRIPTOR_UI":"D007490"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1174,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N06AF05","allCodes":["N06AF05"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iprazid is a small molecule inhibitor of the enzyme monoamine oxidase. It is classified as a monoamine oxidase inhibitor, a drug class that inhibits the action of monoamine oxidase.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}