{"id":"ipriflavone","rwe":[{"pmid":"41096435","year":"2025","title":"Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.","finding":"","journal":"Animals : an open access journal from MDPI","studyType":"Clinical Study"},{"pmid":"40837020","year":"2025","title":"Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine and diabetic mice.","finding":"","journal":"Frontiers in bioengineering and biotechnology","studyType":"Clinical Study"},{"pmid":"39631714","year":"2025","title":"Biochemical investigation and in silico analysis of the therapeutic efficacy of Ipriflavone through Tet-1 Surface-Modified-PLGA nanoparticles in Streptozotocin-Induced Alzheimer's like Disease: Reduced oxidative damage and etiological Descriptors.","finding":"","journal":"International journal of pharmaceutics","studyType":"Clinical Study"},{"pmid":"39490191","year":"2025","title":"Metabolomic characterization of MC3T3-E1pre-osteoblast differentiation induced by ipriflavone-loaded mesoporous nanospheres.","finding":"","journal":"Biomaterials advances","studyType":"Clinical Study"},{"pmid":"39404163","year":"2024","title":"Tandem Acylation and Aromatization of Vinylogous Esters: A Regiospecific Approach to Resorcinyl Ketones.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"}],"tags":[{"label":"ipriflavone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sodium-dependent noradrenaline transporter","category":"target"},{"label":"SLC6A2","category":"gene"},{"label":"PTGS1","category":"gene"},{"label":"M05BX01","category":"atc"},{"label":"Active","category":"status"},{"label":"Postmenopausal osteoporosis","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"osten","offLabel":[],"synonyms":["7-isopropoxyisoflavone","ipriflavone","iprivone","iprosten","osteofix","osten"],"timeline":[],"approvals":[],"brandName":"Osten","ecosystem":[{"indication":"Postmenopausal osteoporosis","otherDrugs":[{"name":"alendronic acid","slug":"alendronic-acid","company":"Merck And Co Inc"},{"name":"bazedoxifene","slug":"bazedoxifene","company":"Wyeth Pharms Pfizer"},{"name":"calcitonin (salmon synthetic)","slug":"calcitonin-(salmon-synthetic)","company":"Sanofi Aventis Us"},{"name":"calcium citrate","slug":"calcium-citrate","company":""}],"globalPrevalence":200000000}],"mechanism":{"target":"Sodium-dependent noradrenaline transporter","targets":[{"gene":"SLC6A2","source":"DrugCentral","target":"Sodium-dependent noradrenaline transporter","protein":"Sodium-dependent noradrenaline transporter"},{"gene":"PTGS1","source":"DrugCentral","target":"Prostaglandin G/H synthase 1","protein":"Prostaglandin G/H synthase 1"}],"modality":"Small Molecule","drugClass":"ipriflavone","explanation":"Think of bone metabolism like a bank account. When you're young, your body is constantly depositing and withdrawing bone tissue. As you age, especially after menopause, your body starts to withdraw more bone tissue than it deposits, leading to osteoporosis. Osten helps to slow down this withdrawal process by blocking the transporter that regulates the withdrawal of bone tissue.","oneSentence":"Osten works by inhibiting the sodium-dependent noradrenaline transporter, which helps to regulate bone metabolism.","technicalDetail":"Osten (IPRIFLAVONE) acts as a selective inhibitor of the sodium-dependent noradrenaline transporter (NET), which is involved in the regulation of bone metabolism through the modulation of osteoclast activity and bone resorption."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Osten","title":"Osten","extract":"Osten is a municipality in the district of Cuxhaven, in Lower Saxony, Germany. It is situated on the river Oste. Osten also means \"East\" in German.","wiki_history":"==History==\nOsten belonged to the Prince-Archbishopric of Bremen, established in 1180. In 1648 the Prince-Archbishopric was transformed into the Duchy of Bremen, which was first ruled in personal union by the Swedish Crown - interrupted by a Danish occupation (1712–1715) - and from 1715 on by the Hanoverian Crown. The Kingdom of Hanover incorporated the Duchy in a real union and the Ducal territory became part of the new Stade Region, established in 1823."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1477","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=IPRIFLAVONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IPRIFLAVONE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Osten","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T12:09:17.826943","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:52:08.081536+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"aluminium chlorohydrate","drugSlug":"aluminium-chlorohydrate","fdaApproval":"","relationship":"same-class"},{"drugName":"denosumab","drugSlug":"denosumab","fdaApproval":"2010-06-01","relationship":"same-class"},{"drugName":"burosumab","drugSlug":"burosumab","fdaApproval":"2018-04-17","relationship":"same-class"},{"drugName":"romosozumab","drugSlug":"romosozumab","fdaApproval":"2019-04-09","relationship":"same-class"},{"drugName":"vosoritide","drugSlug":"vosoritide","fdaApproval":"2021-11-19","patentExpiry":"May 20, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"colecalciferol","drugSlug":"colecalciferol","fdaApproval":"2000-05-18","relationship":"same-class"}],"genericName":"ipriflavone","indications":{"approved":[{"name":"Postmenopausal osteoporosis","source":"DrugCentral","snomedId":102447009,"regulator":"FDA","usPrevalence":10000000,"globalPrevalence":200000000,"prevalenceMethod":"curated","prevalenceSource":"IOF, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aluminium-chlorohydrate","brandName":"aluminium chlorohydrate","genericName":"aluminium chlorohydrate","approvalYear":"","relationship":"same-class"},{"drugId":"denosumab","brandName":"denosumab","genericName":"denosumab","approvalYear":"2010","relationship":"same-class"},{"drugId":"burosumab","brandName":"burosumab","genericName":"burosumab","approvalYear":"2018","relationship":"same-class"},{"drugId":"romosozumab","brandName":"romosozumab","genericName":"romosozumab","approvalYear":"2019","relationship":"same-class"},{"drugId":"vosoritide","brandName":"vosoritide","genericName":"vosoritide","approvalYear":"2021","relationship":"same-class"},{"drugId":"colecalciferol","brandName":"colecalciferol","genericName":"colecalciferol","approvalYear":"2000","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07236190","phase":"PHASE1,PHASE2","title":"Biomarker-based Trial of NPC-1 for Alzheimer's Pathology","status":"NOT_YET_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2026-03","conditions":["Alzheimer Disease","Mild Cognitive Impairment (MCI)","Subjective Cognitive Complaints (SCCs)"],"enrollment":40,"completionDate":"2027-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000186568","NDDF":"004192","UNII":"80BJ7WN25Z","VUID":"4032065","CHEBI":"CHEBI:31719","VANDF":"4032065","INN_ID":"3521","RXNORM":"51487","UMLSCUI":"C0123903","ChEMBL_ID":"CHEMBL165790","KEGG_DRUG":"D01338","DRUGBANK_ID":"DB13618","PUBCHEM_CID":"3747","MESH_SUPPLEMENTAL_RECORD_UI":"C018986"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":289,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"M05BX01","allCodes":["M05BX01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sep 29","pmid":"41096435","title":"Ipriflavone Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection via RIG-I/IRF3-Mediated Interferon Signaling.","journal":"Animals : an open access journal from MDPI"},{"date":"2025","pmid":"40837020","title":"Ipriflavone ameliorates intervertebral disc degeneration by inhibiting osteoporosis of vertebral body and pyroptosis of the nucleus pulposus in instability of lumbar spine and diabetic mice.","journal":"Frontiers in bioengineering and biotechnology"},{"date":"2025 Jan 25","pmid":"39631714","title":"Biochemical investigation and in silico analysis of the therapeutic efficacy of Ipriflavone through Tet-1 Surface-Modified-PLGA nanoparticles in Streptozotocin-Induced Alzheimer's like Disease: Reduced oxidative damage and etiological Descriptors.","journal":"International journal of pharmaceutics"},{"date":"2025 Jan","pmid":"39490191","title":"Metabolomic characterization of MC3T3-E1pre-osteoblast differentiation induced by ipriflavone-loaded mesoporous nanospheres.","journal":"Biomaterials advances"},{"date":"2024 Nov 1","pmid":"39404163","title":"Tandem Acylation and Aromatization of Vinylogous Esters: A Regiospecific Approach to Resorcinyl Ketones.","journal":"The Journal of organic chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Osten is a small molecule with the synonyms 7-ISOPROPOXYISOFLAVONE, IPRIFLAVONA, IPRIFLAVONE, IPRIFLAVONE, NSC-755888.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:52:08.081536+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}