{"id":"ipratropium-levosalbutamol-fixed-dose-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Nervousness"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ipratropium is an anticholinergic agent that blocks muscarinic receptors in airway smooth muscle, preventing acetylcholine-induced bronchoconstriction. Levosalbutamol (the active R-enantiomer of albuterol) is a short-acting beta-2 agonist that binds to beta-2 adrenergic receptors, increasing intracellular cAMP and causing smooth muscle relaxation. Together, they provide complementary bronchodilation through different pathways.","oneSentence":"This combination drug relaxes airway muscles through dual action: ipratropium blocks acetylcholine receptors to reduce bronchoconstriction, while levosalbutamol stimulates beta-2 adrenergic receptors to promote bronchodilation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:49.003Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD)"},{"name":"Asthma (acute bronchospasm relief)"}]},"trialDetails":[{"nctId":"NCT06040424","phase":"PHASE3","title":"Comparison of Ipratropium / Levosalbutamol Fixed Dose Combination and Ipratropium and Levosalbutamol Free Dose Combination in pMDI Form in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients","status":"UNKNOWN","sponsor":"Neutec Ar-Ge San ve Tic A.Ş","startDate":"2023-09-28","conditions":"COPD","enrollment":74},{"nctId":"NCT05890638","phase":"PHASE3","title":"Comparison of Ipratropium / Levosalbutamol Fixed Dose Combination and Ipratropium and Levosalbutamol Free Dose Combination Nebuliser Solutions in Stable Chronic Obstructive Pulmonary Disease (COPD) Patients","status":"UNKNOWN","sponsor":"Neutec Ar-Ge San ve Tic A.Ş","startDate":"2023-08-25","conditions":"COPD","enrollment":74},{"nctId":"NCT04446637","phase":"PHASE3","title":"Acute Bronchodilator Effects of Ipratropium/Levosalbutamol 20/50 mcg Fixed Dose Combination vs Salbutamol 100 mcg Inhaler Plus Ipratropium 20 mcg Inhalation Aerosol Free Combination in Patients With Stable COPD","status":"WITHDRAWN","sponsor":"Neutec Ar-Ge San ve Tic A.Ş","startDate":"2021-09-03","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":""},{"nctId":"NCT01331694","phase":"","title":"Outcomes and Costs Associated With Initiating Maintenance Treatment With Fluticasone Propionate 250mcg/Salmeterol Xinafoate 50mcg Combination (FSC) Versus Anticholinergics Including Tiotropium (TIO) in Patients With Chronic Obstructive Pulmonary Disease (COPD)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-07","conditions":"Pulmonary Disease, Chronic Obstructive","enrollment":76130}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ipratropium / Levosalbutamol Fixed Dose Combination","genericName":"Ipratropium / Levosalbutamol Fixed Dose Combination","companyName":"Neutec Ar-Ge San ve Tic A.Ş","companyId":"neutec-ar-ge-san-ve-tic-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination drug relaxes airway muscles through dual action: ipratropium blocks acetylcholine receptors to reduce bronchoconstriction, while levosalbutamol stimulates beta-2 adrenergic receptors to promote bronchodilation. Used for Chronic obstructive pulmonary disease (COPD), Asthma (acute bronchospasm relief).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}