{"id":"ipidacrine","rwe":[{"pmid":"41782533","year":"2026","title":"[Systematic review and meta-analysis of clinical trials of the efficacy and safety of ipidacrine for the treatment of peripheral neuropathies].","finding":"","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","studyType":"Clinical Study"},{"pmid":"41661017","year":"2026","title":"[Efficacy and safety of ipidacrine (Neuromidin) in patients with diabetic polyneuropathy: results of an open-label comparative study].","finding":"","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","studyType":"Clinical Study"},{"pmid":"41058457","year":"2025","title":"PREVENTION OF PACLITAXEL-INDUCED MOTOR NEUROPATHY OF FIBULAR AND TIBIAL NERVES WITH ALPHA-LIPOIC ACID AND IPIDACRIN HYDROCHLORIDE IN BREAST CANCER PATIENTS.","finding":"","journal":"Experimental oncology","studyType":"Clinical Study"},{"pmid":"40879236","year":"2025","title":"[Algorithm for the diagnosis and treatment of patients with diabetic polyneuropathy. Expert Council Resolution (March 1, 2025)].","finding":"","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","studyType":"Clinical Study"},{"pmid":"40353541","year":"2025","title":"[Pharmacological correction of burning eye syndrome].","finding":"","journal":"Vestnik oftalmologii","studyType":"Clinical Study"}],"tags":[{"label":"ipidacrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Acetylcholinesterase","category":"target"},{"label":"ACHE","category":"gene"},{"label":"N06DA05","category":"atc"},{"label":"Active","category":"status"},{"label":"Alzheimer's disease","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"amiridine","offLabel":[],"synonyms":["ipidacrine hydrochloride hydrate","CV71VTP0VN","ipidacrine","neuromidine","ipidacrine hydrochloride","NIK-247","amiridine","ipidacrine HCl"],"timeline":[],"approvals":[],"brandName":"Amiridine","ecosystem":[{"indication":"Alzheimer's disease","otherDrugs":[{"name":"aducanumab","slug":"aducanumab","company":"Biogen Inc"},{"name":"donepezil","slug":"donepezil","company":"Eisai Inc"},{"name":"epicriptine","slug":"epicriptine","company":""},{"name":"galantamine","slug":"galantamine","company":"Janssen Pharms"}],"globalPrevalence":55000000}],"mechanism":{"target":"Acetylcholinesterase","targets":[{"gene":"ACHE","source":"DrugCentral","target":"Acetylcholinesterase","protein":"Acetylcholinesterase"}],"modality":"Small Molecule","drugClass":"ipidacrine","explanation":"Think of acetylcholine like a key that unlocks memories and helps us learn. When acetylcholinesterase breaks it down, the key is destroyed and can't do its job. By blocking this enzyme, Amiridine allows more acetylcholine to build up in the brain, helping to improve memory and cognitive function.","oneSentence":"Amiridine works by inhibiting the enzyme Acetylcholinesterase, which breaks down the neurotransmitter acetylcholine.","technicalDetail":"Amiridine acts as a reversible cholinesterase inhibitor, competitively binding to the active site of Acetylcholinesterase and preventing the hydrolysis of acetylcholine, thereby increasing its concentration and duration of action in the synaptic cleft."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ipidacrine","title":"Ipidacrine","extract":"Ipidacrine (Neiromidin) is a drug first synthesized by the National Research Center for Biologically Active Compounds in the Russian Federation. This compound is a modification of the older drug tacrine (Cognex)."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4808","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IPIDACRINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ipidacrine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T12:08:49.912939","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:49:58.464153+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"tacrine","drugSlug":"tacrine","fdaApproval":"1993-09-09","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"donepezil","drugSlug":"donepezil","fdaApproval":"1996-11-25","patentExpiry":"Sep 23, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"rivastigmine","drugSlug":"rivastigmine","fdaApproval":"2000-04-21","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"galantamine","drugSlug":"galantamine","fdaApproval":"2001-02-28","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"memantine","drugSlug":"memantine","fdaApproval":"2003-10-16","patentExpiry":"Sep 24, 2029","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"ipidacrine","indications":{"approved":[{"name":"Alzheimer's disease","source":"DrugCentral","snomedId":26929004,"regulator":"FDA","usPrevalence":6700000,"globalPrevalence":55000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"tacrine","brandName":"tacrine","genericName":"tacrine","approvalYear":"1993","relationship":"same-class"},{"drugId":"donepezil","brandName":"donepezil","genericName":"donepezil","approvalYear":"1996","relationship":"same-class"},{"drugId":"rivastigmine","brandName":"rivastigmine","genericName":"rivastigmine","approvalYear":"2000","relationship":"same-class"},{"drugId":"galantamine","brandName":"galantamine","genericName":"galantamine","approvalYear":"2001","relationship":"same-class"},{"drugId":"memantine","brandName":"memantine","genericName":"memantine","approvalYear":"2003","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"CV71VTP0VN","CHEBI":"CHEBI:125612","INN_ID":"7385","UMLSCUI":"C0051691","ChEMBL_ID":"CHEMBL130880","KEGG_DRUG":"D09750","DRUGBANK_ID":"DB13668","PDB_CHEM_ID":"R9W","PUBCHEM_CID":"604519","MESH_SUPPLEMENTAL_RECORD_UI":"C049860"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":38,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N06DA05","allCodes":["N06DA05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026","pmid":"41782533","title":"[Systematic review and meta-analysis of clinical trials of the efficacy and safety of ipidacrine for the treatment of peripheral neuropathies].","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova"},{"date":"2026","pmid":"41661017","title":"[Efficacy and safety of ipidacrine (Neuromidin) in patients with diabetic polyneuropathy: results of an open-label comparative study].","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova"},{"date":"2025 Oct 7","pmid":"41058457","title":"PREVENTION OF PACLITAXEL-INDUCED MOTOR NEUROPATHY OF FIBULAR AND TIBIAL NERVES WITH ALPHA-LIPOIC ACID AND IPIDACRIN HYDROCHLORIDE IN BREAST CANCER PATIENTS.","journal":"Experimental oncology"},{"date":"2025","pmid":"40879236","title":"[Algorithm for the diagnosis and treatment of patients with diabetic polyneuropathy. Expert Council Resolution (March 1, 2025)].","journal":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova"},{"date":"2025","pmid":"40353541","title":"[Pharmacological correction of burning eye syndrome].","journal":"Vestnik oftalmologii"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amiridine is a small molecule. It is also known by the synonyms IPIDACRINA, IPIDACRINE, and IPIDACRINE.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:49:58.464153+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}