{"id":"ip-lignocaine-bolus-and-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness or lightheadedness"},{"rate":null,"effect":"Tremor or twitching"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Seizures (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL4650310","moleculeType":"Small molecule","molecularWeight":"271.32"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lignocaine works by reversibly binding to voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby inhibiting the influx of sodium ions. This prevents depolarization and blocks the generation and propagation of action potentials in sensory and motor nerves. When administered intravenously as a bolus or infusion, it can provide systemic analgesic and anti-arrhythmic effects in addition to local anesthetic properties.","oneSentence":"Lignocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:06.522Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia"},{"name":"Ventricular arrhythmias (intravenous formulation)"}]},"trialDetails":[{"nctId":"NCT03105193","phase":"PHASE4","title":"Intravenous and Intraperitoneal Lignocaine for Perioperative Analgesia in Laparoscopic Colon Resections","status":"COMPLETED","sponsor":"University of Auckland, New Zealand","startDate":"2018-08-17","conditions":"Laparoscopic Colon Resection, Perioperative Analgesia","enrollment":60},{"nctId":"NCT02707081","phase":"PHASE2, PHASE3","title":"Efficacy of Intraperitoneal Versus Intravenous Lidocaine for Postcesarean Pain Relief","status":"COMPLETED","sponsor":"Benha University","startDate":"2013-06","conditions":"Postcesarean Pain Relief","enrollment":150},{"nctId":"NCT01608373","phase":"PHASE4","title":"The Effect of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation on Pain After Laparoscopic Cholecystectomy","status":"UNKNOWN","sponsor":"Chung-Ang University Hosptial, Chung-Ang University College of Medicine","startDate":"2011-07","conditions":"Postoperative Pain","enrollment":83},{"nctId":"NCT01717222","phase":"PHASE4","title":"Effect of Intraperitoneal and Intravenous Lignocaine on Pain Relief Following Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Jawaharlal Institute of Postgraduate Medical Education & Research","startDate":"2011-12","conditions":"Pain, Postoperative, Analgesic Requirement, Stress Response","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"IP Lignocaine bolus and infusion","genericName":"IP Lignocaine bolus and infusion","companyName":"University of Auckland, New Zealand","companyId":"university-of-auckland-new-zealand","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lignocaine (lidocaine) is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia, Ventricular arrhythmias (intravenous formulation).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}