{"id":"ioversol-320-mgi-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Contrast-induced nephropathy (acute kidney injury)"},{"rate":null,"effect":"Allergic reaction (rash, urticaria)"},{"rate":null,"effect":"Anaphylaxis"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Flushing and warmth sensation"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ioversol contains iodine atoms that absorb X-rays more strongly than surrounding soft tissues, creating contrast that allows radiologists to visualize vascular structures, organs, and pathology on X-ray and CT imaging. The non-ionic formulation reduces osmolality compared to ionic contrast agents, which decreases the risk of adverse reactions and renal toxicity. It is administered intravenously and distributes throughout the intravascular and extracellular compartments before being renally eliminated.","oneSentence":"Ioversol is a non-ionic, iodinated contrast medium that increases radiodensity in blood vessels and tissues to enhance visualization during radiographic imaging procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:09.749Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contrast enhancement for coronary angiography and cardiac imaging"},{"name":"Contrast enhancement for peripheral vascular angiography"},{"name":"Contrast enhancement for cerebral angiography"},{"name":"Contrast enhancement for CT imaging of the abdomen, pelvis, and thorax"}]},"trialDetails":[{"nctId":"NCT00793182","phase":"PHASE4","title":"Effects of Contrast Media on Subjects With Stable Reduced Renal Function Undergoing Contrast-Enhanced Computed Tomography","status":"TERMINATED","sponsor":"Guerbet","startDate":"2009-01","conditions":"Renal Impairment","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Optiray"],"phase":"marketed","status":"active","brandName":"Ioversol 320 mgI/mL","genericName":"Ioversol 320 mgI/mL","companyName":"Guerbet","companyId":"guerbet","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ioversol is a non-ionic, iodinated contrast medium that increases radiodensity in blood vessels and tissues to enhance visualization during radiographic imaging procedures. Used for Contrast enhancement for coronary angiography and cardiac imaging, Contrast enhancement for peripheral vascular angiography, Contrast enhancement for cerebral angiography.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}