{"id":"iopodic-acid","rwe":[],"tags":[{"label":"iopodic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V08AC08","category":"atc"},{"label":"Active","category":"status"},{"label":"Diagnostic aid","category":"indication"},{"label":"Bracco","category":"company"},{"label":"Approved 1960s","category":"decade"},{"label":"Contrast Media","category":"pharmacology"},{"label":"Diagnostic Uses of Chemicals","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Acute nephropathy","Asthma","Hb SS disease","Hepatic failure","Hypertensive Emergencies","Kidney disease","Pheochromocytoma","Pregnancy, function"]},"trials":[],"aliases":[],"company":"Bracco","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=iopodic acid","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:53:34.768112+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Iopodic Acid","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:53:43.707768+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T00:53:58.467079+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:53:41.536560+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=iopodic acid","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:53:42.597830+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201243/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:53:43.594005+00:00"}},"allNames":"ipodate","offLabel":[],"synonyms":["ipodate","oragrafin sodium","iopodic acid","bilimin acid","bilopten","oragrafin","calcium iopodate","ipodate sodium","sodium iopodate","ipodate calcium"],"timeline":[{"date":"1962-03-15","type":"positive","source":"DrugCentral","milestone":"FDA approval (Bracco)"}],"aiSummary":"Iopodic acid (Ipodate), marketed by Bracco, is a diagnostic aid used for visualizing the thyroid gland during imaging procedures, competing in a class with several established alternatives such as iodoxamic acid, adipiodone, iopanoic acid, iocetamic acid, and tyropanoate. Its key strength lies in its mechanism of action, which allows for effective thyroid visualization, supported by a key composition patent expiring in 2028. The primary risk to Ipodate's market position is the presence of multiple same-class competitors, some of which have been on the market since the 1950s, potentially limiting its market share growth.","approvals":[{"date":"1962-03-15","orphan":false,"company":"BRACCO","regulator":"FDA"}],"brandName":"Ipodate","ecosystem":[{"indication":"Diagnostic aid","otherDrugs":[{"name":"ceruletide","slug":"ceruletide","company":"Pharmacia And Upjohn"},{"name":"iopanoic acid","slug":"iopanoic-acid","company":""},{"name":"sincalide","slug":"sincalide","company":"Bracco"},{"name":"technetium Tc 99m tilmanocept","slug":"technetium-tc-99m-tilmanocept","company":"Navidea Biopharms"}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"iopodic acid","explanation":"","oneSentence":"","technicalDetail":"Ipodate is a radiopaque contrast agent that selectively accumulates in the thyroid gland, likely through a combination of passive diffusion and active transport mechanisms, allowing for enhanced visualization during diagnostic imaging procedures."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Ipodate_sodium","title":"Ipodate sodium","extract":"Ipodate sodium is an iodine-containing radiopaque contrast media used for X-rays. The drug is given orally and the resulting contrast allows for easy resolution of the bile duct and gall bladder."},"commercial":{"launchDate":"1962","_launchSource":"DrugCentral (FDA 1962-03-15, BRACCO)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1474","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=iopodic acid","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Ipodate_sodium","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T15:01:45.231840","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:53:58.467419+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"iodoxamic acid","drugSlug":"iodoxamic-acid","fdaApproval":"1981-08-14","relationship":"same-class"},{"drugName":"adipiodone","drugSlug":"adipiodone","fdaApproval":"1954-04-27","relationship":"same-class"},{"drugName":"iopanoic acid","drugSlug":"iopanoic-acid","fdaApproval":"1951-07-16","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"iocetamic acid","drugSlug":"iocetamic-acid","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tyropanoate","drugSlug":"tyropanoate","fdaApproval":"1969-10-24","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"iopodic acid","indications":{"approved":[{"name":"Diagnostic aid","source":"DrugCentral","snomedId":2949005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"iodoxamic-acid","brandName":"iodoxamic acid","genericName":"iodoxamic acid","approvalYear":"1981","relationship":"same-class"},{"drugId":"adipiodone","brandName":"adipiodone","genericName":"adipiodone","approvalYear":"1954","relationship":"same-class"},{"drugId":"iopanoic-acid","brandName":"iopanoic acid","genericName":"iopanoic acid","approvalYear":"1951","relationship":"same-class"},{"drugId":"iocetamic-acid","brandName":"iocetamic acid","genericName":"iocetamic acid","approvalYear":"","relationship":"same-class"},{"drugId":"tyropanoate","brandName":"tyropanoate","genericName":"tyropanoate","approvalYear":"1969","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000178897","MMSL":"2949","NDDF":"001226","UNII":"F316LLW9WW","VUID":"4017623","CHEBI":"CHEBI:81496","VANDF":"4017623","INN_ID":"1033","RXNORM":"1911","UMLSCUI":"C4082438","chemblId":"CHEMBL1201243","ChEMBL_ID":"CHEMBL1201243","KEGG_DRUG":"D01015","DRUGBANK_ID":"DB09333","PUBCHEM_CID":"5241","SNOMEDCT_US":"395877001","SECONDARY_CAS_RN":"1221-56-3","MESH_DESCRIPTOR_UI":"D007487"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"1962-","companyName":"Bracco","relationship":"Original Developer"}],"publicationCount":3,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"V08AC08","allCodes":["V08AC08","V08AC10"]},"biosimilarFilings":[],"originalDeveloper":"Bracco","recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Bracco","companyId":"bracco","modality":"Small Molecule","firstApprovalDate":"1962","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1962-03-15T00:00:00.000Z","mah":"BRACCO","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:53:58.467419+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}