{"id":"iopentol","rwe":[{"pmid":"34479049","year":"2021","title":"Photon interaction performance of various contrast agents: Theoretical and simulation results.","finding":"","journal":"Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine","studyType":"Clinical Study"},{"pmid":"30172537","year":"2018","title":"A rapid and easy method based on hydrophilic interaction chromatography coupled with tandem mass spectrometry (HILIC-MS/MS/MS) to quantify iodinated X-ray contrast in wastewaters.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"23242291","year":"2012","title":"Cost-effectiveness of iso- versus low-osmolality contrast media in outpatients with high risk of contrast medium-induced nephropathy.","finding":"","journal":"Biomedica : revista del Instituto Nacional de Salud","studyType":"Clinical Study"},{"pmid":"22596231","year":"2013","title":"Influence of a radiographic contrast media (Iopentol) with different viscosities on capillary perfusion in patients with coronary artery disease.","finding":"","journal":"Clinical hemorheology and microcirculation","studyType":"Clinical Study"},{"pmid":"19996728","year":"2010","title":"Contrast-induced acute kidney injury in patients with renal dysfunction undergoing a coronary procedure and receiving non-ionic low-osmolar versus iso-osmolar contrast media.","finding":"","journal":"The American journal of the medical sciences","studyType":"Clinical Study"}],"tags":[{"label":"iopentol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V08AB08","category":"atc"},{"label":"Active","category":"status"},{"label":"Contrast Media","category":"pharmacology"},{"label":"Diagnostic Uses of Chemicals","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["iopentol"],"offLabel":[],"synonyms":["iopentol"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"iopentol","explanation":"Think of it like a key that fits into a lock in the brain or other parts of the body. When it binds to the lock, it can either turn it on or off, or change how it works. This can affect how the body responds to certain signals or stimuli.","oneSentence":"Iopentol is a small molecule that works by modulating the activity of certain enzymes or receptors in the body.","technicalDetail":"Iopentol is a small molecule that acts as a modulator of enzyme activity, potentially influencing various physiological processes through its interaction with specific molecular targets."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1466","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IOPENTOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:59:29.096084","biosimilars":[],"competitors":[{"drugName":"metrizamide","drugSlug":"metrizamide","fdaApproval":"1978-08-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"iohexol","drugSlug":"iohexol","fdaApproval":"1985-12-26","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ioxaglic acid","drugSlug":"ioxaglic-acid","fdaApproval":"1985-07-26","relationship":"same-class"},{"drugName":"iopamidol","drugSlug":"iopamidol","fdaApproval":"1985-12-31","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"iopromide","drugSlug":"iopromide","fdaApproval":"1995-05-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"iotrolan","drugSlug":"iotrolan","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"ioversol","drugSlug":"ioversol","fdaApproval":"1988-12-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"iodixanol","drugSlug":"iodixanol","fdaApproval":"1996-03-22","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ioxilan","drugSlug":"ioxilan","fdaApproval":"1995-12-21","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"iopentol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"metrizamide","brandName":"metrizamide","genericName":"metrizamide","approvalYear":"1978","relationship":"same-class"},{"drugId":"iohexol","brandName":"iohexol","genericName":"iohexol","approvalYear":"1985","relationship":"same-class"},{"drugId":"ioxaglic-acid","brandName":"ioxaglic acid","genericName":"ioxaglic acid","approvalYear":"1985","relationship":"same-class"},{"drugId":"iopamidol","brandName":"iopamidol","genericName":"iopamidol","approvalYear":"1985","relationship":"same-class"},{"drugId":"iopromide","brandName":"iopromide","genericName":"iopromide","approvalYear":"1995","relationship":"same-class"},{"drugId":"iotrolan","brandName":"iotrolan","genericName":"iotrolan","approvalYear":"","relationship":"same-class"},{"drugId":"ioversol","brandName":"ioversol","genericName":"ioversol","approvalYear":"1988","relationship":"same-class"},{"drugId":"iodixanol","brandName":"iodixanol","genericName":"iodixanol","approvalYear":"1996","relationship":"same-class"},{"drugId":"ioxilan","brandName":"ioxilan","genericName":"ioxilan","approvalYear":"1995","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006220","UNII":"7D6XWX076T","INN_ID":"5580","RXNORM":"27779","UMLSCUI":"C0063815","ChEMBL_ID":"CHEMBL2104783","KEGG_DRUG":"D04582","DRUGBANK_ID":"DB13861","PUBCHEM_CID":"56016","MESH_SUPPLEMENTAL_RECORD_UI":"C053571"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"2.04 hours","clearance":"1.27 mL/min/kg","fractionUnbound":"1.0%","volumeOfDistribution":"0.2 L/kg"},"publicationCount":90,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"V08AB08","allCodes":["V08AB08"]},"biosimilarFilings":[],"recentPublications":[{"date":"2021 Nov","pmid":"34479049","title":"Photon interaction performance of various contrast agents: Theoretical and simulation results.","journal":"Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine"},{"date":"2018 Dec 1","pmid":"30172537","title":"A rapid and easy method based on hydrophilic interaction chromatography coupled with tandem mass spectrometry (HILIC-MS/MS/MS) to quantify iodinated X-ray contrast in wastewaters.","journal":"Talanta"},{"date":"2012 Jun","pmid":"23242291","title":"Cost-effectiveness of iso- versus low-osmolality contrast media in outpatients with high risk of contrast medium-induced nephropathy.","journal":"Biomedica : revista del Instituto Nacional de Salud"},{"date":"2013","pmid":"22596231","title":"Influence of a radiographic contrast media (Iopentol) with different viscosities on capillary perfusion in patients with coronary artery disease.","journal":"Clinical hemorheology and microcirculation"},{"date":"2010 Jan","pmid":"19996728","title":"Contrast-induced acute kidney injury in patients with renal dysfunction undergoing a coronary procedure and receiving non-ionic low-osmolar versus iso-osmolar contrast media.","journal":"The American journal of the medical sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"IOPENTOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iopentol is a small molecule drug of the iopentol class, but its target and approved indications are unknown. Its commercial status, including whether it is patented or generic, and whether it is off-patent, is also unclear. The half-life of iopentol is approximately 2.04 hours, but its bioavailability is unknown. As a result, there is limited information available about this drug. Further research is needed to understand its properties and potential uses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}