{"id":"iopanoic-acid","rwe":[],"tags":[{"label":"iopanoic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V08AC06","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Diagnostic aid","category":"indication"},{"label":"Approved 1950s","category":"decade"},{"label":"Contrast Media","category":"pharmacology"},{"label":"Diagnostic Uses of Chemicals","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Acute nephropathy","Asthma","Hb SS disease","Hepatic failure","Hypertensive Emergencies","Kidney disease","Pheochromocytoma","Pregnancy, function"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=IOPANOIC ACID","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:43:25.139078+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T00:00:48.200460+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:43:30.636378+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IOPANOIC ACID","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:43:30.879496+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL867/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:43:32.548629+00:00"}},"allNames":"iopanoicum","offLabel":[],"synonyms":["iopanoic acid","iopanoicum","iodopanoic acid","iodopanic acid"],"timeline":[{"date":"1951-07-16","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Iopanoic Acid (Iopanoicum) is a marketed diagnostic aid used for imaging the gallbladder and bile ducts, with a key composition patent expiring in 2028. Its primary strength lies in its established mechanism of being taken up by the liver and excreted in the bile, facilitating clear imaging. The primary risk is the presence of several same-class competitors, including iodoxamic acid, adipiodone, iocetamic acid, iopodic acid, and tyropanoate, which may limit market share and revenue growth.","approvals":[{"date":"1951-07-16","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Iopanoicum","ecosystem":[{"indication":"Diagnostic aid","otherDrugs":[{"name":"ceruletide","slug":"ceruletide","company":"Pharmacia And Upjohn"},{"name":"iopodic acid","slug":"iopodic-acid","company":"Bracco"},{"name":"sincalide","slug":"sincalide","company":"Bracco"},{"name":"technetium Tc 99m tilmanocept","slug":"technetium-tc-99m-tilmanocept","company":"Navidea Biopharms"}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"iopanoic acid","explanation":"","oneSentence":"","technicalDetail":"Iopanoic acid is a small molecule that is taken up by the liver via an unknown mechanism, and then excreted in the bile, where it can be visualized using imaging techniques such as cholecystography."},"commercial":{"launchDate":"1951","_launchSource":"DrugCentral (FDA 1951-07-16, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1465","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IOPANOIC ACID","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T12:08:14.905564","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:43:34.191148+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"iodoxamic 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