{"id":"iodothiouracil","rwe":[],"tags":[{"label":"iodothiouracil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"iothiouracil","offLabel":[],"synonyms":["iodothiouracil","iothiouracil","5-Iodo-2-thiouracil"],"timeline":[],"approvals":[],"brandName":"Iothiouracil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"iodothiouracil","explanation":"Think of it like a brake on a car - iodothiouracil puts the brakes on the thyroid gland's ability to make thyroid hormones, which are like the 'gas pedal' for the body's metabolism. By slowing down hormone production, iodothiouracil can help reduce the symptoms of hyperthyroidism, a condition where the thyroid gland produces too many hormones.","oneSentence":"Iothiouracil works by inhibiting the synthesis of thyroid hormones.","technicalDetail":"Iothiouracil is a competitive inhibitor of the enzyme thyroid peroxidase (TPO), which is essential for the synthesis of thyroid hormones. By binding to TPO, iodothiouracil prevents the enzyme from converting iodine into a form that can be used to make thyroid hormones, thereby reducing hormone production."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1458","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IODOTHIOURACIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:07:49.137279","biosimilars":[],"competitors":[],"genericName":"iodothiouracil","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"61O17612T5","CHEBI":"CHEBI:135037","INN_ID":"222","UMLSCUI":"C0063799","ChEMBL_ID":"CHEMBL1697840","PUBCHEM_CID":"3032445","SNOMEDCT_US":"387255008","MESH_SUPPLEMENTAL_RECORD_UI":"C036667"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":9,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iothiouracil is a small molecule with synonyms including IODOTHIOURACIL, IODOTIOURACILO, and IOTHIOURACIL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}