{"id":"iodophor-0-7-and-ipa-74-w-w","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Allergic contact dermatitis (iodine sensitivity)"},{"rate":null,"effect":"Drying of skin"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Iodophors are iodine-based complexes that release free iodine, which denatures proteins and disrupts microbial cell membranes and nucleic acids. The 74% isopropyl alcohol component provides rapid surface disinfection and evaporative drying. Together, they provide broad-spectrum antimicrobial coverage against bacteria, viruses, fungi, and spores, making this suitable for skin antisepsis and disinfection.","oneSentence":"This topical antiseptic formulation kills microorganisms through the antimicrobial action of iodine complexed with a carrier molecule, combined with the rapid bactericidal and virucidal effects of isopropyl alcohol.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:06.751Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin antisepsis and disinfection"},{"name":"Preoperative skin preparation"},{"name":"Wound disinfection"}]},"trialDetails":[{"nctId":"NCT00739583","phase":"PHASE4","title":"Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2008-08","conditions":"Arthroplasty, Replacement, Hip","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Duraprep® (Iodophor 0.7% and IPA 74% w/w; 3M Healthcare, St. Paul, MN, USA)"],"phase":"marketed","status":"active","brandName":"Iodophor 0.7% and IPA 74% w/w","genericName":"Iodophor 0.7% and IPA 74% w/w","companyName":"Johns Hopkins University","companyId":"johns-hopkins-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This topical antiseptic formulation kills microorganisms through the oxidative and protein-denaturing properties of iodine combined with the rapid antimicrobial action of isopropyl alcohol. Used for Skin antisepsis and disinfection prior to medical procedures, Wound cleansing and antisepsis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}