{"id":"iodocholesterol-131i","rwe":[{"pmid":"7013159","year":"1981","title":"3-Ethyl and 3-methyl ethers of 19-iodocholesterol as potential adrenal scanning agents.","finding":"","journal":"Steroids","studyType":"Clinical Study"},{"pmid":"7421434","year":"1980","title":"[Improvement in the quality of 19-iodocholesterol-131I scintigraphy by using polysponin].","finding":"","journal":"Meditsinskaia radiologiia","studyType":"Clinical Study"},{"pmid":"215865","year":"1979","title":"[Use of pharmacological preparations for the purpose of improving the visualization of the adrenals with 19-iodocholesterol-131I].","finding":"","journal":"Meditsinskaia radiologiia","studyType":"Clinical Study"},{"pmid":"342859","year":"1978","title":"[Scintigraphy of the adrenals using 19-iodocholesterol-131I].","finding":"","journal":"Meditsinskaia radiologiia","studyType":"Clinical Study"},{"pmid":"1017078","year":"1976","title":"A comparison of 19-iodocholesterol-131I with 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol-131I as an adrenal-scanning agent.","finding":"","journal":"Chemical & pharmaceutical bulletin","studyType":"Clinical Study"}],"tags":[{"label":"iodocholesterol (131I)","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V09XA02","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":["NCT00037843"],"aliases":[],"patents":[],"pricing":[],"allNames":"iodocholesterol i 131","offLabel":[],"synonyms":["iodocholesterol (131I)","Iodocholesterol I 131"],"timeline":[],"approvals":[],"brandName":"Iodocholesterol I 131","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"iodocholesterol (131I)","explanation":"This is achieved through the use of radioactive iodine, which is taken up by thyroid cells and causes cell death. The radioactive iodine is selectively taken up by thyroid cells because they have a high affinity for iodine, allowing for targeted treatment of thyroid cancer. This targeted approach helps to minimize damage to surrounding healthy tissue.","oneSentence":"Iodocholesterol I 131 works by selectively targeting and destroying cancer cells in the thyroid gland.","technicalDetail":"Iodocholesterol (131I) is a radioactive form of the cholesterol molecule, which is selectively taken up by thyroid cells via the sodium-iodide symporter (NIS). Once inside the cell, the radioactive iodine emits beta particles, causing DNA damage and cell death."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Iodocholesterol","title":"Iodocholesterol","extract":"Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (131I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical. When the iodine atom is a radioactive isotope, it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma, and adrenal remnants following total adrenalectomy."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4578","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=iodocholesterol (131I)","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Iodocholesterol","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T13:59:06.194104","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"iodocholesterol (131i)","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00037843","phase":"Phase 3","title":"Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","isPivotal":true,"enrollment":114,"indication":"Adrenal Gland Diseases, Adrenal Gland Neoplasms","completionDate":"2007-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"C5F4248GPJ","CHEBI":"CHEBI:135998","INN_ID":"4443","UMLSCUI":"C0304983","ChEMBL_ID":"CHEMBL2105011","KEGG_DRUG":"D04567","DRUGBANK_ID":"DB13797","PUBCHEM_CID":"450510"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Oncology"],"atcClassification":{"source":"DrugCentral","atcCode":"V09XA02","allCodes":["V09XA02"]},"biosimilarFilings":[],"recentPublications":[{"date":"1981 Feb","pmid":"7013159","title":"3-Ethyl and 3-methyl ethers of 19-iodocholesterol as potential adrenal scanning agents.","journal":"Steroids"},{"date":"1980 Sep","pmid":"7421434","title":"[Improvement in the quality of 19-iodocholesterol-131I scintigraphy by using polysponin].","journal":"Meditsinskaia radiologiia"},{"date":"1979 Jan","pmid":"215865","title":"[Use of pharmacological preparations for the purpose of improving the visualization of the adrenals with 19-iodocholesterol-131I].","journal":"Meditsinskaia radiologiia"},{"date":"1978 Jan","pmid":"342859","title":"[Scintigraphy of the adrenals using 19-iodocholesterol-131I].","journal":"Meditsinskaia radiologiia"},{"date":"1976 Oct","pmid":"1017078","title":"A comparison of 19-iodocholesterol-131I with 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol-131I as an adrenal-scanning agent.","journal":"Chemical & pharmaceutical bulletin"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Iodocholesterol I 131 (iodocholesterol (131I)) is a small molecule radiopharmaceutical in the iodocholesterol class. Unfortunately, there is limited information available on this compound, including its target, approved indications, and commercial status. As a result, it is difficult to provide a comprehensive summary of its use and safety considerations. Further research is needed to fully understand the properties and applications of iodocholesterol (131I).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}