{"id":"iodixanol-ioversol-iopromide","safety":{"commonSideEffects":[{"rate":"1-25","effect":"Contrast-induced nephropathy"},{"rate":"1-3","effect":"Allergic reaction (mild)"},{"rate":"0.01-0.1","effect":"Anaphylaxis"},{"rate":"5-15","effect":"Nausea and vomiting"},{"rate":"20-50","effect":"Flushing and warmth sensation"},{"rate":"1-5","effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Iodixanol, ioversol, and iopromide are non-ionic, iodinated radiographic contrast agents used in angiography and other imaging studies. The iodine atoms have high atomic number and attenuate X-rays effectively, creating enhanced contrast between vascular structures and surrounding tissues. They are administered intravenously and distribute throughout the vascular and extracellular compartments to improve diagnostic imaging quality.","oneSentence":"These are iodinated contrast media that increase radiodensity to enhance visualization of blood vessels and organs during imaging procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:06.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Coronary angiography and percutaneous coronary intervention"},{"name":"Peripheral vascular angiography"},{"name":"Cerebral angiography"},{"name":"Renal angiography"},{"name":"Computed tomography imaging enhancement"}]},"trialDetails":[{"nctId":"NCT03631771","phase":"PHASE4","title":"Pediatric Risk of Hypothyroidism With Iodinated Contrast Media","status":"WITHDRAWN","sponsor":"GE Healthcare","startDate":"2022-03","conditions":"Hypothyroidism","enrollment":""},{"nctId":"NCT04908826","phase":"NA","title":"Comparison of Icg's Route of Administration During Laparoscopic Cholecystectomy","status":"UNKNOWN","sponsor":"Aristotle University Of Thessaloniki","startDate":"2022-01-03","conditions":"Laparoscopic; Cholecystectomy, Cholelithiasis; Bile Duct, Choledocholithiasis","enrollment":240},{"nctId":"NCT00335101","phase":"PHASE4","title":"Renal Effects of Three Iodinated Contrast Media (CM) in Patients at Risk Undergoing Coronary Angiography","status":"WITHDRAWN","sponsor":"GE Healthcare","startDate":"2006-06","conditions":"Coronary Artery Disease (CAD), Renal Impairment, Diabetes Mellitus","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":31,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Iodixanol, Ioversol, Iopromide","genericName":"Iodixanol, Ioversol, Iopromide","companyName":"GE Healthcare","companyId":"ge-healthcare","modality":"Small molecule","firstApprovalDate":"","aiSummary":"These are iodinated contrast media that increase radiodensity to enhance visualization of blood vessels and organs during imaging procedures. Used for Coronary angiography and percutaneous coronary intervention, Peripheral vascular angiography, Cerebral angiography.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}