{"id":"iocetamic-acid","rwe":[{"pmid":"20641974","year":"2004","title":"Sodium-2-[(3-butanoylamino-2,4,6-triiodo-phenyl)methyl]butanoate.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"6230004","year":"1984","title":"Severe thrombocytopenia following oral cholecystography with iocetamic acid.","finding":"","journal":"American journal of hematology","studyType":"Clinical Study"},{"pmid":"6221659","year":"1983","title":"Severe thrombocytopenia following oral cholecystography with iocetamic acid.","finding":"","journal":"American journal of hematology","studyType":"Clinical Study"},{"pmid":"6449974","year":"1981","title":"A comparative trial of three oral cholecystographic contrast media--iocetamic acid, iopanoic acid and sodium ipodate.","finding":"","journal":"The British journal of radiology","studyType":"Clinical Study"},{"pmid":"6452657","year":"1980","title":"[Comparative study with a closed sequential design between iopronic and iocetamic acid in oral cholecystocholangiography with radiograms in short and standard times. Laboratory evaluation of hepatic function (author's transl)].","finding":"","journal":"La Radiologia medica","studyType":"Clinical Study"}],"tags":[{"label":"iocetamic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V08AC07","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Mallinckrodt","category":"company"}],"phase":"marketed","safety":{"contraindications":["Acute nephropathy","Asthma","Hb SS disease","Hepatic failure","Hypertensive Emergencies","Kidney disease","Pheochromocytoma","Pregnancy, function"]},"trials":[],"aliases":[],"company":"Mallinckrodt","patents":[],"pricing":[],"allNames":"cholebrine","offLabel":[],"synonyms":["iocetamic acid","cholebrine"],"timeline":[],"aiSummary":"Cholebrine, also known as iocetamic acid, is a small molecule drug developed by Mallinckrodt. Its target and approved indications are unknown, and it is currently off-patent with no active Orange Book patents. As a result, there are no generic manufacturers. The drug's pharmacokinetic properties, including half-life and bioavailability, are also unknown. Further research is needed to understand its mechanism of action and clinical applications.","approvals":[{"date":"","orphan":false,"company":"MALLINCKRODT","regulator":"FDA"}],"brandName":"Cholebrine","ecosystem":[],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"iocetamic acid","explanation":"Imagine your body's cells have locks on them, and Cholebrine is a key that fits into one of those locks. When it binds, it can either block or enhance the activity of the cell, but we don't know which yet. More research is needed to understand how it interacts with cells and tissues.","oneSentence":"Cholebrine works by binding to a specific target, although its exact mechanism of action is currently unknown.","technicalDetail":"Cholebrine's mechanism of action is currently unknown, but it is classified as a small molecule drug, suggesting it may interact with proteins or receptors on cell surfaces to produce its effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1451","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=IOCETAMIC ACID","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T14:58:12.186611","biosimilars":[],"competitors":[{"drugName":"iodoxamic acid","drugSlug":"iodoxamic-acid","fdaApproval":"1981-08-14","relationship":"same-class"},{"drugName":"adipiodone","drugSlug":"adipiodone","fdaApproval":"1954-04-27","relationship":"same-class"},{"drugName":"iopanoic acid","drugSlug":"iopanoic-acid","fdaApproval":"1951-07-16","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"iopodic acid","drugSlug":"iopodic-acid","fdaApproval":"1962-03-15","relationship":"same-class"},{"drugName":"tyropanoate","drugSlug":"tyropanoate","fdaApproval":"1969-10-24","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"iocetamic acid","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"iodoxamic-acid","brandName":"iodoxamic acid","genericName":"iodoxamic acid","approvalYear":"1981","relationship":"same-class"},{"drugId":"adipiodone","brandName":"adipiodone","genericName":"adipiodone","approvalYear":"1954","relationship":"same-class"},{"drugId":"iopanoic-acid","brandName":"iopanoic acid","genericName":"iopanoic acid","approvalYear":"1951","relationship":"same-class"},{"drugId":"iopodic-acid","brandName":"iopodic acid","genericName":"iopodic acid","approvalYear":"1962","relationship":"same-class"},{"drugId":"tyropanoate","brandName":"tyropanoate","genericName":"tyropanoate","approvalYear":"1969","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"_patentsChecked":true,"crossReferences":{"NUI":"N0000146505","MMSL":"7482","NDDF":"001232","UNII":"FA675Q0E3E","VUID":"4018168","CHEBI":"CHEBI:91662","VANDF":"4018168","INN_ID":"2347","RXNORM":"183830","UMLSCUI":"C0650160","ChEMBL_ID":"CHEMBL1200770","KEGG_DRUG":"D04563","DRUGBANK_ID":"DB09403","PUBCHEM_CID":"27648","MESH_SUPPLEMENTAL_RECORD_UI":"C073259"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"Mallinckrodt","relationship":"Original Developer"}],"publicationCount":19,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"V08AC07","allCodes":["V08AC07"]},"biosimilarFilings":[],"originalDeveloper":"Mallinckrodt","recentPublications":[{"date":"2004","pmid":"20641974","title":"Sodium-2-[(3-butanoylamino-2,4,6-triiodo-phenyl)methyl]butanoate.","journal":""},{"date":"1984 Jan","pmid":"6230004","title":"Severe thrombocytopenia following oral cholecystography with iocetamic acid.","journal":"American journal of hematology"},{"date":"1983 May","pmid":"6221659","title":"Severe thrombocytopenia following oral cholecystography with iocetamic acid.","journal":"American journal of hematology"},{"date":"1981 Jan","pmid":"6449974","title":"A comparative trial of three oral cholecystographic contrast media--iocetamic acid, iopanoic acid and sodium ipodate.","journal":"The British journal of radiology"},{"date":"1980 Jul-Aug","pmid":"6452657","title":"[Comparative study with a closed sequential design between iopronic and iocetamic acid in oral cholecystocholangiography with radiograms in short and standard times. Laboratory evaluation of hepatic function (author's transl)].","journal":"La Radiologia medica"}],"companionDiagnostics":[],"genericManufacturers":0,"_genericFilersChecked":true,"genericManufacturerList":[],"status":"approved","companyName":"Mallinckrodt","companyId":"mallinckrodt","modality":"Small molecule","firstApprovalDate":"1982","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"MALLINCKRODT","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"enriching","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}