{"id":"invossa-k-inj","safety":{"commonSideEffects":[{"rate":null,"effect":"Joint pain or swelling"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Transient fever or systemic inflammation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Invossa K uses an allogeneic human chondrocyte cell line transduced with a retroviral vector carrying the TGF-β1 gene. When injected into the knee joint, these modified cells produce TGF-β1 locally, which promotes cartilage matrix synthesis and reduces inflammatory responses, thereby slowing or reversing osteoarthritic damage.","oneSentence":"Invossa K is a gene therapy that delivers TGF-β1 to stimulate cartilage regeneration and reduce joint degeneration in osteoarthritis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:00.176Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis of the knee (Phase 3)"}]},"trialDetails":[{"nctId":"NCT03412864","phase":"","title":"A Post Marketing Surveillance Study of INVOSSA K Inj.","status":"UNKNOWN","sponsor":"Kolon Life Science","startDate":"2017-07-12","conditions":"Osteoarthritis","enrollment":3000},{"nctId":"NCT03383471","phase":"PHASE3","title":"The Efficacy and Safety of Invossa K Injection in Patients Diagnosed With Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Kolon Life Science","startDate":"2018-02-12","conditions":"Osteoarthritis","enrollment":146}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Invossa K Inj.","genericName":"Invossa K Inj.","companyName":"Kolon Life Science","companyId":"kolon-life-science","modality":"Biologic","firstApprovalDate":"","aiSummary":"Invossa K Inj. is a protein-based treatment used to study the safety and effectiveness in patients with osteoarthritis. It is being evaluated in a post-marketing surveillance study, NCT03412864, conducted by Kolon Life Science.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}