{"id":"investigational-varicella-vaccine-lot-2","safety":{"commonSideEffects":[{"rate":"20–30%","effect":"Injection site reactions (erythema, swelling, pain)"},{"rate":"10–15%","effect":"Fever"},{"rate":"3–5%","effect":"Rash"},{"rate":"5–10%","effect":"Myalgia or arthralgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Varicella vaccines work by presenting viral antigens (typically attenuated or inactivated virus components) to the immune system, triggering both humoral and cellular immune responses. This priming allows the body to rapidly recognize and neutralize varicella-zoster virus upon natural exposure, preventing chickenpox infection or reducing disease severity.","oneSentence":"This vaccine stimulates the immune system to recognize and prevent varicella-zoster virus infection by inducing protective antibodies and cell-mediated immunity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:03.727Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in pediatric and adult populations"}]},"trialDetails":[{"nctId":"NCT06740630","phase":"PHASE3","title":"A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age","status":"RECRUITING","sponsor":"GlaxoSmithKline","startDate":"2025-01-10","conditions":"Chickenpox","enrollment":1840}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Investigational varicella vaccine_Lot 2","genericName":"Investigational varicella vaccine_Lot 2","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"This vaccine stimulates the immune system to recognize and prevent varicella-zoster virus infection by inducing protective antibodies and cell-mediated immunity. Used for Prevention of varicella (chickenpox) in pediatric and adult populations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}