{"id":"investigational-varicella-vaccine-lot-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site erythema or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Myalgia or arthralgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Varicella vaccines work by introducing attenuated or inactivated varicella-zoster virus antigen to prime both humoral and cellular immune responses. This allows the body to mount a rapid and effective immune response upon exposure to wild-type virus, preventing primary infection (chickenpox) or reducing disease severity. The vaccine trains memory B and T cells to recognize viral epitopes.","oneSentence":"This investigational vaccine stimulates the immune system to recognize and prevent varicella-zoster virus infection by inducing protective antibodies and cell-mediated immunity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:04.413Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in pediatric and/or adult populations"}]},"trialDetails":[{"nctId":"NCT06740630","phase":"PHASE3","title":"A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age","status":"RECRUITING","sponsor":"GlaxoSmithKline","startDate":"2025-01-10","conditions":"Chickenpox","enrollment":1840}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Investigational varicella vaccine_Lot 1","genericName":"Investigational varicella vaccine_Lot 1","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"This investigational vaccine stimulates the immune system to recognize and prevent varicella-zoster virus infection by inducing protective antibodies and cell-mediated immunity. Used for Prevention of varicella (chickenpox) in pediatric and/or adult populations.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}