{"id":"intrinsa-transdermal-testosterone-patch","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation at application site"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Hirsutism"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Mood changes"}]},"_chembl":{"chemblId":"CHEMBL1200335","moleculeType":"Small molecule","molecularWeight":"400.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Testosterone is an androgen that acts on androgen receptors throughout the body and brain to regulate sexual desire and arousal. The transdermal patch formulation allows continuous delivery of testosterone across the skin, bypassing first-pass hepatic metabolism and maintaining steady-state hormone levels. This restores testosterone concentrations to the normal physiological range in postmenopausal women, thereby improving sexual function and desire.","oneSentence":"Intrinsa delivers testosterone transdermally to restore physiological testosterone levels in women with hypoactive sexual desire disorder.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:01.184Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypoactive sexual desire disorder in postmenopausal women"}]},"trialDetails":[{"nctId":"NCT06733350","phase":"PHASE4","title":"Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance","status":"SUSPENDED","sponsor":"Roswell Park Cancer Institute","startDate":"2025-01-15","conditions":"Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8","enrollment":600},{"nctId":"NCT06455969","phase":"PHASE4","title":"Adaptions and Resiliency to Multi-Stressor OpeRations","status":"RECRUITING","sponsor":"Bradley Nindl","startDate":"2024-07-15","conditions":"Musculoskeletal Injury, Hypogonadism","enrollment":120},{"nctId":"NCT01208038","phase":"PHASE4","title":"Testosterone Patch's Effects on the Cardiovascular System and Libido","status":"COMPLETED","sponsor":"Imperial College Healthcare NHS Trust","startDate":"2011-03","conditions":"Hypoactive Sexual Desire Disorder","enrollment":22},{"nctId":"NCT00266864","phase":"PHASE2, PHASE3","title":"Testosterone Replacement Therapy in Chronic Spinal Cord Injury","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2003-08","conditions":"Spinal Cord Injury, Hypogonadism","enrollment":31},{"nctId":"NCT00586898","phase":"PHASE2","title":"Rapid Hormonal Cycling as Treatment for Patients With Prostate Cancer: The Men's Cycle","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2001-07","conditions":"Prostate, Cancer, Hormonal Cycling","enrollment":36},{"nctId":"NCT01096329","phase":"PHASE1","title":"A Pharmacokinetic (PK) Study to Compare the Absorption of Two Formulations of Transdermal Testosterone Spray and Intrinsa®","status":"TERMINATED","sponsor":"VIVUS LLC","startDate":"2010-02","conditions":"Hypoactive Sexual Desire Disorder","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Intrinsa"],"phase":"marketed","status":"active","brandName":"Intrinsa Transdermal testosterone patch","genericName":"Intrinsa Transdermal testosterone patch","companyName":"Imperial College Healthcare NHS Trust","companyId":"imperial-college-healthcare-nhs-trust","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intrinsa delivers testosterone transdermally to restore physiological testosterone levels in women with hypoactive sexual desire disorder. Used for Hypoactive sexual desire disorder in postmenopausal women.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}