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The direct intravitreal administration allows for rapid antimicrobial action against bacteria colonizing the posterior segment of the eye.","oneSentence":"Intravitreal antibiotics are antimicrobial agents injected directly into the vitreous cavity of the eye to treat or prevent bacterial infections within the eye.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:46.003Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial endophthalmitis"},{"name":"Intraocular bacterial infection prophylaxis"}]},"trialDetails":[{"nctId":"NCT06890026","phase":"","title":"Durability of Three Monthly Loading Doses With Faricimab in Treatment-naïve Neovascular Age-related Macular Degeneration","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2024-11-15","conditions":"Neovascular Age-Related Macular Degeneration (nAMD), Treatment-naïve","enrollment":742},{"nctId":"NCT04981860","phase":"PHASE4","title":"Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine","status":"SUSPENDED","sponsor":"University of Miami","startDate":"2021-08-06","conditions":"Eye Infections, Bacterial","enrollment":230},{"nctId":"NCT04522661","phase":"NA","title":"A Feasibility Randomised Controlled Trial of Early Vitrectomy for Post-operative Exogenous Endophthalmitis","status":"COMPLETED","sponsor":"Moorfields Eye Hospital NHS Foundation Trust","startDate":"2021-08-12","conditions":"Endophthalmitis Postoperative Acute","enrollment":63},{"nctId":"NCT06902207","phase":"","title":"Real-world Incidence of Intraocular Inflammation Following Intravitreal Faricimab Therapy","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2024-11-10","conditions":"Intraocular Inflammation","enrollment":6053},{"nctId":"NCT06879301","phase":"EARLY_PHASE1","title":"Effectiveness of Intravitreal Injection of Aflibercept 8 mg in Resistant Diabetic Macular Edema, Retinal Vein Occlusion and Myopic Choroidal Neovascularisation Patients","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2025-10-19","conditions":"Diabetic Macular Edema (DME), Retinal Vein Occlusion (RVO), Myopic Choroidal Neovascularisation","enrollment":60},{"nctId":"NCT04192994","phase":"NA","title":"Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2019-01-01","conditions":"Endophthalmitis","enrollment":25},{"nctId":"NCT04707209","phase":"NA","title":"Sirolimus for Retinal Astrocytic Hamartoma","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2020-11-04","conditions":"Retinal Astrocytic Hamartoma","enrollment":1},{"nctId":"NCT06231121","phase":"","title":"Switching to Faricimab in Neovascular Age-related Macular Degeneration Resistant to Both Aflibercept and Ranibizumab","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2023-12-01","conditions":"Neovascular Age-related Macular Degeneration","enrollment":13},{"nctId":"NCT06124677","phase":"","title":"Single Injection of Faricimab for nAMD With Persisting Fluid Despite Frequent Aflibercept Treatments","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2023-11-01","conditions":"Neovascular Age-related Macular Degeneration","enrollment":46},{"nctId":"NCT04035369","phase":"NA","title":"Endophthalmitis Post Intravitreal Injections","status":"UNKNOWN","sponsor":"Unity Health Toronto","startDate":"2020-03-01","conditions":"Endophthalmitis","enrollment":310},{"nctId":"NCT05701124","phase":"PHASE3","title":"Intravitreal Ranibizumab Injection for Aggressive Versus Type 1 Prethreshold Retinopathy of Prematurity","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2020-11-20","conditions":"Retina Disease, Retinopathy of Prematurity, Ranibizumab","enrollment":30},{"nctId":"NCT02015351","phase":"NA","title":"Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - 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