{"id":"intravesical-antibiotic-instillation","safety":{"commonSideEffects":[{"rate":null,"effect":"Dysuria"},{"rate":null,"effect":"Urinary frequency"},{"rate":null,"effect":"Bladder irritation"},{"rate":null,"effect":"Hematuria"},{"rate":null,"effect":"Local allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This treatment involves instilling antibiotic solutions directly into the bladder via catheter, allowing high local concentrations of antimicrobial agents to contact the bladder urothelium and eliminate or suppress pathogenic bacteria. The direct bladder delivery minimizes systemic absorption and side effects while providing sustained local antimicrobial activity. This approach is commonly used for prophylaxis in patients with recurrent UTIs, neurogenic bladder, or following urological interventions.","oneSentence":"Intravesical antibiotic instillation delivers antibiotics directly into the bladder to prevent or treat urinary tract infections, particularly recurrent infections and those associated with urological procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:18.971Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Recurrent urinary tract infections"},{"name":"Prophylaxis for urological procedures"},{"name":"Neurogenic bladder management"},{"name":"Prevention of catheter-associated urinary tract infections"}]},"trialDetails":[{"nctId":"NCT04323735","phase":"PHASE2","title":"Intravesical Lactobacillus for Urinary Symptoms Among People With NLUTD Who Use Indwelling Catheters","status":"RECRUITING","sponsor":"Medstar Health Research Institute","startDate":"2020-01-10","conditions":"Neurogenic Bladder","enrollment":182},{"nctId":"NCT04095572","phase":"PHASE4","title":"Alternative Prophylaxis in Female Recurrent Urinary Tract Infections","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2020-10-27","conditions":"Urinary Tract Infections, Urinary Tract Infection (UTI)","enrollment":50},{"nctId":"NCT02948543","phase":"PHASE3","title":"Adding Mitomycin to BCG as Adjuvant Intravesical Therapy for High-risk Non-Muscle-invasive Bladder Cancer","status":"UNKNOWN","sponsor":"University of Sydney","startDate":"2013-07","conditions":"Bladder Cancer","enrollment":501},{"nctId":"NCT04285320","phase":"PHASE4","title":"Antibiotic Bladder Instillations vs. Oral Suppression for the Treatment of Recurrent Urinary Tract Infections","status":"UNKNOWN","sponsor":"Atlantic Health System","startDate":"2021-03","conditions":"Recurrent Urinary Tract Infection","enrollment":100},{"nctId":"NCT01799499","phase":"NA","title":"A Prospective Open Label Comparative Dose Ranging Study Evaluating the Effect of Pre-TURBT Intravesical Instillation of Mitomycin C (MMC) Mixed With TC-3 Gel in Patients With Non Muscle Invasive Bladder Cancer (NMIBC)","status":"WITHDRAWN","sponsor":"UroGen Pharma Ltd.","startDate":"2013-03","conditions":"Non Muscle Invasive Bladder Cancer","enrollment":""},{"nctId":"NCT02016118","phase":"","title":"Retrospective Analysis of Ialuril vs. Standard of Care in Recurrent Urinary Tract Infections","status":"UNKNOWN","sponsor":"Study Group for Urogenital Diseases, Italy","startDate":"2014-01","conditions":"Recurrent Urinary Tract Infections","enrollment":500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intravesical antibiotic instillation","genericName":"Intravesical antibiotic instillation","companyName":"Atlantic Health System","companyId":"atlantic-health-system","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravesical antibiotic instillation delivers antibiotics directly into the bladder to prevent or treat urinary tract infections, particularly recurrent infections and those associated with urological procedures. Used for Recurrent urinary tract infections, Prophylaxis for urological procedures, Neurogenic bladder management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}