{"id":"intravenous-tirofiban-before-endovascular-thrombectomy","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding complications"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Intracranial hemorrhage"}]},"_chembl":{"chemblId":"CHEMBL3189072","moleculeType":"Small molecule","molecularWeight":"495.08"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tirofiban reversibly binds to the glycoprotein IIb/IIIa receptor on platelet surfaces, blocking the final common pathway of platelet aggregation by preventing fibrinogen cross-linking. When administered intravenously before endovascular thrombectomy, it reduces thrombotic complications and improves reperfusion outcomes in acute ischemic stroke patients by maintaining vessel patency and preventing thrombus reformation during mechanical clot retrieval.","oneSentence":"Tirofiban is a platelet glycoprotein IIb/IIIa inhibitor that prevents platelet aggregation and thrombus formation during endovascular thrombectomy for acute ischemic stroke.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:49.498Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke undergoing endovascular thrombectomy"}]},"trialDetails":[{"nctId":"NCT05225961","phase":"PHASE4","title":"ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","startDate":"2022-05-01","conditions":"Acute Ischemic Stroke","enrollment":240},{"nctId":"NCT05728333","phase":"PHASE2, PHASE3","title":"Intravenous Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Stroke","status":"RECRUITING","sponsor":"Xinqiao Hospital of Chongqing","startDate":"2023-11-28","conditions":"Stroke, Acute Ischemic","enrollment":800},{"nctId":"NCT07135089","phase":"PHASE3","title":"Improving Neuroprotective Strategy for Ischemic Stroke Before Endovascular Thrombectomy by Intravenous Tirofiban","status":"RECRUITING","sponsor":"General Hospital of Shenyang Military Region","startDate":"2025-11-13","conditions":"Stroke, Ischemic","enrollment":870},{"nctId":"NCT05902000","phase":"NA","title":"Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion","status":"UNKNOWN","sponsor":"Xueli Cai","startDate":"2023-06-14","conditions":"Thrombectomy, Tandem Occlusion, Stroke","enrollment":222}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intravenous tirofiban before endovascular thrombectomy","genericName":"Intravenous tirofiban before endovascular thrombectomy","companyName":"General Hospital of Shenyang Military Region","companyId":"general-hospital-of-shenyang-military-region","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tirofiban is a platelet glycoprotein IIb/IIIa inhibitor that prevents platelet aggregation and thrombus formation during endovascular thrombectomy for acute ischemic stroke. Used for Acute ischemic stroke undergoing endovascular thrombectomy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}