{"id":"intravenous-thrombolysis-plus-tirofiban","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding/hemorrhage"},{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intravenous thrombolysis (likely alteplase or similar fibrinolytic agent) breaks down existing thrombi by converting plasminogen to plasmin. Tirofiban is a glycoprotein IIb/IIIa inhibitor that blocks platelet aggregation by preventing fibrinogen binding to activated platelets. Together, they aim to restore blood flow while reducing thrombotic recurrence.","oneSentence":"This combination uses intravenous thrombolysis to dissolve blood clots while tirofiban inhibits platelet aggregation to prevent clot reformation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:54.143Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke"},{"name":"Acute myocardial infarction"}]},"trialDetails":[{"nctId":"NCT06210633","phase":"","title":"Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke","status":"RECRUITING","sponsor":"Zhongming Qiu","startDate":"2024-01-20","conditions":"Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion","enrollment":1000},{"nctId":"NCT06045156","phase":"NA","title":"Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke","status":"RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2024-04-29","conditions":"Acute Ischemic Stroke","enrollment":1084},{"nctId":"NCT05728333","phase":"PHASE2, PHASE3","title":"Intravenous Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Stroke","status":"RECRUITING","sponsor":"Xinqiao Hospital of Chongqing","startDate":"2023-11-28","conditions":"Stroke, Acute Ischemic","enrollment":800},{"nctId":"NCT05604638","phase":"PHASE3","title":"Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Second Affiliated Hospital of Guangxi Medical University","startDate":"2024-04-24","conditions":"Acute Ischemic Stroke","enrollment":348},{"nctId":"NCT07290751","phase":"PHASE4","title":"Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke","status":"RECRUITING","sponsor":"Beijing Anzhen Hospital","startDate":"2025-11-11","conditions":"Acute Ischemic Stroke","enrollment":976},{"nctId":"NCT06134622","phase":"PHASE3","title":"Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis (ASSET-IT)","status":"COMPLETED","sponsor":"The First Affiliated Hospital of University of Science and Technology of China","startDate":"2024-03-14","conditions":"Acute Ischemic Stroke","enrollment":832},{"nctId":"NCT06587347","phase":"PHASE2, PHASE3","title":"Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Capital Medical University","startDate":"2024-11-20","conditions":"Acute Stroke, Ischemic Stroke, Acute, Cerebral Infarction","enrollment":302},{"nctId":"NCT05735301","phase":"NA","title":"Patient Selection Using MR With Non-Perfusion Imaging for Endovascular Treatment Within 6 to 24 Hours","status":"RECRUITING","sponsor":"Tianjin Huanhu Hospital","startDate":"2019-01-01","conditions":"Endovascular Thrombectomy","enrollment":352},{"nctId":"NCT05733507","phase":"","title":"Tirofiban Plus Intravenous Thrombolysis in Acute Anterior Choroidal Infarction or Paramedian Pontine Infarction","status":"COMPLETED","sponsor":"Centre Hospitalier Sud Francilien","startDate":"2023-04-03","conditions":"Acute Anterior Choroidal Infarction (ACI), Paramedian Pontine Infarction (IPP)","enrollment":48},{"nctId":"NCT05902000","phase":"NA","title":"Stent Implantation Versus Balloon Dilation for Acute Anterior Circulation Tandem Occlusion","status":"UNKNOWN","sponsor":"Xueli Cai","startDate":"2023-06-14","conditions":"Thrombectomy, Tandem Occlusion, Stroke","enrollment":222},{"nctId":"NCT05188417","phase":"PHASE2","title":"A Study Evaluating the Safety and Efficacy of Tirofiban in Combination With Alteplase in Acute Ischemic Stroke","status":"UNKNOWN","sponsor":"GrandPharma (China) Co., Ltd.","startDate":"2021-12-09","conditions":"Acute Ischemic Stroke","enrollment":266},{"nctId":"NCT03357133","phase":"PHASE2, PHASE3","title":"Tirofiban for Patients Treated With Alteplase","status":"TERMINATED","sponsor":"Capital Medical University","startDate":"2017-12-16","conditions":"Ischemic Stroke","enrollment":30},{"nctId":"NCT00713557","phase":"","title":"Shanghai Registry of Acute Coronary Events","status":"TERMINATED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2005-03","conditions":"Coronary Artery Disease, Acute Coronary Syndrome","enrollment":20000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":22,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intravenous thrombolysis plus tirofiban","genericName":"Intravenous thrombolysis plus tirofiban","companyName":"The First Affiliated Hospital of University of Science and Technology of China","companyId":"the-first-affiliated-hospital-of-university-of-science-and-technology-of-china","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses intravenous thrombolysis to dissolve blood clots while tirofiban inhibits platelet aggregation to prevent clot reformation. Used for Acute ischemic stroke, Acute myocardial infarction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}