{"id":"intravenous-saline-plus-perineural-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS and cardiac effects)"},{"rate":null,"effect":"Local tissue irritation or nerve injury"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a local anesthetic that works by blocking sodium channels in nerve cell membranes, preventing action potential propagation and thus pain signal transmission in the targeted nerve region. When administered perineural (around a nerve), it provides regional anesthesia and postoperative analgesia. The intravenous saline component maintains fluid and electrolyte balance during the procedure.","oneSentence":"Intravenous saline provides fluid and electrolyte support while perineural bupivacaine blocks nerve conduction locally to provide regional anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:58.768Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and postoperative pain management via perineural nerve blocks"}]},"trialDetails":[{"nctId":"NCT06810882","phase":"NA","title":"Intravenous Versus Perineural Ondansetron for Laparoscopic Sleeve Gastrectomy","status":"RECRUITING","sponsor":"Tanta University","startDate":"2025-02-16","conditions":"Ondansetron, Laparoscopic, Gastrectomy","enrollment":170},{"nctId":"NCT05215158","phase":"NA","title":"Intravenous Versus Peribulbar Dexmedetomidine for Strabismus Surgery in Adults","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2022-01-28","conditions":"Squint","enrollment":46},{"nctId":"NCT04561856","phase":"PHASE4","title":"Fascia Iliaca Block Supplemented With Perineural Vs Intravenous Dexamethasone","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-09-30","conditions":"Postoperative Pain","enrollment":99},{"nctId":"NCT04345588","phase":"PHASE2","title":"Dexamethasone as an Adjuvant in Supraclavicular Block","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-01-01","conditions":"Dexamethasone Efficacy as an Adjuvant in Supraclavicular Block","enrollment":60},{"nctId":"NCT03885804","phase":"EARLY_PHASE1","title":"Perineural Versus IV Dexmedetomidine as Adjuvant to Quadratus Lamborum Block for Pediatrics Undergoing Pyeloplasty","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2019-03-20","conditions":"Pain, Postoperative","enrollment":50},{"nctId":"NCT02506660","phase":"PHASE4","title":"Interscalene Block With Low-dose IV vs. Perineural Dexamethasone for Shoulder Arthroscopy","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2015-08","conditions":"Pain, Shoulder Arthroscopy","enrollment":128},{"nctId":"NCT02576782","phase":"PHASE4","title":"Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries","status":"COMPLETED","sponsor":"Sherif Mohamed Abd el moneim Soaida, MD","startDate":"2013-06","conditions":"Pain","enrollment":63}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"intravenous saline plus perineural bupivacaine","genericName":"intravenous saline plus perineural bupivacaine","companyName":"Sherif Mohamed Abd el moneim Soaida, MD","companyId":"sherif-mohamed-abd-el-moneim-soaida-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous saline provides fluid and electrolyte support while perineural bupivacaine blocks nerve conduction locally to provide regional anesthesia and analgesia. Used for Regional anesthesia and postoperative pain management via perineural nerve blocks.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}