{"id":"intravenous-saline-0-9","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Phlebitis at infusion site"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Intravenous saline 0.9%","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T06:46:35.273838+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T06:46:50.880612+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T06:46:41.944809+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Intravenous saline 0.9%","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T06:46:42.782135+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108783/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T06:46:43.292649+00:00"}},"_dailymed":null,"aiSummary":"Intravenous saline 0.9%, marketed by the University of Nottingham, is a well-established product in the healthcare sector. The key composition patent is set to expire in 2028, providing a period of exclusive protection. The primary risk is the potential increase in competition post-patent expiry.","mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Normal saline (0.9% NaCl) is an isotonic crystalloid fluid that matches the osmolarity of blood plasma, allowing safe expansion of intravascular volume without causing cellular water shifts. It replaces lost fluids and electrolytes in dehydration, hemorrhage, and perioperative settings, and serves as a vehicle for medication delivery.","oneSentence":"Intravenous saline 0.9% restores fluid and electrolyte balance by delivering isotonic sodium chloride solution directly into the bloodstream.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:53.829Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T06:46:50.881823+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Hypovolemia and dehydration"},{"name":"Perioperative fluid replacement"},{"name":"Maintenance of vascular access and medication delivery"},{"name":"Hemorrhagic shock (initial resuscitation)"}]},"trialDetails":[{"nctId":"NCT07149649","phase":"PHASE2, PHASE3","title":"Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC)","status":"NOT_YET_RECRUITING","sponsor":"Swiss Cancer Institute","startDate":"2026-07","conditions":"Metastatic NSCLC - Non-Small Cell Lung Cancer","enrollment":230},{"nctId":"NCT04847063","phase":"PHASE1","title":"Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2021-10-19","conditions":"Peritoneal Mesothelioma, Peritoneal Carcinomatosis, Ovarian Cancer","enrollment":60},{"nctId":"NCT06128629","phase":"PHASE3","title":"MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)","status":"RECRUITING","sponsor":"Intellia Therapeutics","startDate":"2023-12-13","conditions":"Transthyretin Amyloidosis (ATTR) With Cardiomyopathy","enrollment":1200},{"nctId":"NCT07494383","phase":"NA","title":"Sphenopalatine Ganglion Block for Post-Dural Puncture Headache: A Pilot Randomised Controlled Trial","status":"COMPLETED","sponsor":"ISSSTE Hospital Regional \"Gral. 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