{"id":"intravenous-lidocaine-ivl","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness or lightheadedness"},{"rate":null,"effect":"Tremor or muscle twitching"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Cardiac arrhythmias (at high doses)"},{"rate":null,"effect":"Seizures (at toxic doses)"}]},"_chembl":{"chemblId":"CHEMBL79","moleculeType":"Small molecule","molecularWeight":"234.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic and antiarrhythmic agent that works by inhibiting sodium influx through voltage-gated sodium channels in excitable tissues. This suppresses the rapid depolarization phase of the action potential, raising the threshold for excitability. When administered intravenously, it is used primarily for acute ventricular arrhythmia suppression and as an adjunctive analgesic in perioperative and chronic pain settings.","oneSentence":"Intravenous lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:53.220Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation)"},{"name":"Perioperative analgesia and anesthesia adjunct"},{"name":"Chronic pain management (off-label)"}]},"trialDetails":[{"nctId":"NCT05238506","phase":"PHASE4","title":"Lidocaine VS Hemodynamic, Metabolic and Hormonal Response","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2022-03-12","conditions":"Hemodynamic Response, Acute Appendicitis, Complication of Treatment","enrollment":132},{"nctId":"NCT03410836","phase":"PHASE4","title":"Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions","status":"UNKNOWN","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2019-04-29","conditions":"Intravenous Lidocaine and Immunity","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"intravenous lidocaine (IVL)","genericName":"intravenous lidocaine (IVL)","companyName":"Ciusss de L'Est de l'Île de Montréal","companyId":"ciusss-de-l-est-de-l-le-de-montr-al","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Acute ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation), Perioperative analgesia and anesthesia adjunct, Chronic pain management (off-label).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}