{"id":"intravenous-ketorolac-tromethamine","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL1201124","moleculeType":"Small molecule","molecularWeight":"376.41"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ketorolac Tromethamine is a racemic mixture of the S- and R-enantiomers of ketorolac. It is a competitive inhibitor of COX enzymes, which are responsible for the conversion of arachidonic acid to prostaglandins. By inhibiting COX enzymes, ketorolac Tromethamine reduces the production of prostaglandins, leading to decreased inflammation and pain.","oneSentence":"Intravenous Ketorolac Tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:55:36.333Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain"},{"name":"Acute pain"}]},"trialDetails":[{"nctId":"NCT05543785","phase":"NA","title":"Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries","status":"RECRUITING","sponsor":"Mansoura University","startDate":"2022-11-01","conditions":"Postoperative Pain, Acute","enrollment":76},{"nctId":"NCT05324358","phase":"PHASE3","title":"Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy","status":"COMPLETED","sponsor":"Neumentum, Inc.","startDate":"2022-12-14","conditions":"Pain, Postoperative","enrollment":341},{"nctId":"NCT07352059","phase":"NA","title":"Midazolam Alone Versus Midazolam With Ketorolac for Sedation During Flexible Bronchoscopy.","status":"NOT_YET_RECRUITING","sponsor":"SYED HAIDER ALI","startDate":"2026-01-20","conditions":"Sedation and Analgesia Management in Patients Undergoing Flexible Bronchoscopy","enrollment":50},{"nctId":"NCT03638999","phase":"EARLY_PHASE1","title":"NSAIDs Stent Study","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2018-07-31","conditions":"Ureteral Stent Placement, Kidney Stone","enrollment":36},{"nctId":"NCT05641363","phase":"PHASE3","title":"Comparison of Ketorolac at Three Doses in Children With Acute Pain","status":"COMPLETED","sponsor":"Hamilton Health Sciences Corporation","startDate":"2023-06-01","conditions":"Acute Pain, Abdominal Pain, Migraine","enrollment":171},{"nctId":"NCT02470299","phase":"NA","title":"Evaluation of GTPase Inhibition by Post-operative Intravenous Ketorolac in Ovarian Cancer Patients","status":"COMPLETED","sponsor":"New Mexico Cancer Research Alliance","startDate":"2015-10-29","conditions":"Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer","enrollment":21},{"nctId":"NCT03987022","phase":"PHASE4","title":"ICE-T Pain Regimen for Total Laparoscopic Hysterectomy","status":"COMPLETED","sponsor":"MetroHealth Medical Center","startDate":"2019-08-01","conditions":"Opioid Substitution Treatment","enrollment":66},{"nctId":"NCT03467750","phase":"PHASE4","title":"Effect of Ketorolac on Post Adenotonsillectomy Pain","status":"COMPLETED","sponsor":"Emory University","startDate":"2018-07-19","conditions":"Obstructive Sleep Apnea","enrollment":63},{"nctId":"NCT02509143","phase":"NA","title":"Acupuncture for Postoperative Nausea and Vomiting in Patients Undergoing Colorectal Surgery","status":"COMPLETED","sponsor":"Pusan National University Yangsan Hospital","startDate":"2015-07","conditions":"Postoperative Nausea and Vomiting, Colorectal Neoplasms","enrollment":60},{"nctId":"NCT04646967","phase":"PHASE2","title":"An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision","status":"COMPLETED","sponsor":"Alberta Children's Hospital","startDate":"2022-11-25","conditions":"Pain, Postoperative, Phimosis, Paraphimosis","enrollment":100},{"nctId":"NCT05875571","phase":"PHASE4","title":"Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement","status":"RECRUITING","sponsor":"Arkansas Children's Hospital Research Institute","startDate":"2024-02-05","conditions":"IUD, Healthy Female, Contraception","enrollment":18},{"nctId":"NCT06160778","phase":"PHASE3","title":"Intravenous Ketorolac Vs. 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Speciality Board","companyId":"oman-medical-speciality-board","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous Ketorolac Tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain. Used for Moderate to severe pain, Acute pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}