{"id":"intravenous-fentanyl-guided-by-soc","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Chest wall rigidity"}]},"_chembl":{"chemblId":"CHEMBL1201159","moleculeType":"Small molecule","molecularWeight":"372.94"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl activates mu-opioid receptors throughout the brain and spinal cord, inhibiting pain signal transmission and producing potent analgesia. When administered intravenously under standard of care (SoC) guidance, it provides rapid onset pain relief and sedation suitable for acute care settings. The 'SoC' designation indicates this is a standard clinical protocol rather than an investigational approach.","oneSentence":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:24.300Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management in hospital/clinical settings"},{"name":"Perioperative analgesia and sedation"}]},"trialDetails":[{"nctId":"NCT03776838","phase":"PHASE4","title":"Impact of Nociceptive-Level (NOL) Intraoperative Guided Analgesia During Gynecological Laparoscopic Surgery Under General Anesthesia","status":"COMPLETED","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2018-11-30","conditions":"Gynecologic Laparoscopic Surgery, Hysterectomy, Oophorectomy","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intravenous Fentanyl guided by SoC","genericName":"Intravenous Fentanyl guided by SoC","companyName":"Ciusss de L'Est de l'Île de Montréal","companyId":"ciusss-de-l-est-de-l-le-de-montr-al","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute pain management in hospital/clinical settings, Perioperative analgesia and sedation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}