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The IV formulation allows for controlled dosing and direct CNS penetration.","oneSentence":"Intravenous esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:49.751Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment-resistant depression (TRD)"},{"name":"Major depressive disorder with acute suicidal ideation or behavior"}]},"trialDetails":[{"nctId":"NCT04480918","phase":"","title":"University of Iowa Interventional Psychiatry Service Patient Registry","status":"RECRUITING","sponsor":"Mark Niciu","startDate":"2020-11-02","conditions":"Treatment Resistant Depression, Major Depressive Episode, Major Depression","enrollment":1000},{"nctId":"NCT07377981","phase":"PHASE4","title":"An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With 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