{"id":"intravenous-ascorbate","safety":{"commonSideEffects":[{"rate":null,"effect":"Infusion site reactions"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hyperglycemia (in susceptible patients)"},{"rate":null,"effect":"Kidney stone risk (chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"At pharmacological doses achieved through intravenous administration, ascorbate generates hydrogen peroxide and other reactive oxygen species that induce oxidative stress in tumor cells, triggering apoptosis. Simultaneously, ascorbate supports immune cell function and may enhance the efficacy of conventional chemotherapy or immunotherapy through multiple mechanisms including collagen synthesis and antioxidant support in normal tissues.","oneSentence":"Intravenous ascorbate (vitamin C) acts as a pro-oxidant at high concentrations to generate reactive oxygen species that selectively kill cancer cells while supporting immune function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:42.140Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced or metastatic cancer (various solid tumors)"},{"name":"Cancer adjunctive therapy in combination with conventional chemotherapy"}]},"trialDetails":[{"nctId":"NCT06991738","phase":"PHASE1, PHASE2","title":"177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2026-04-01","conditions":"Thyroid Cancer","enrollment":18},{"nctId":"NCT02905591","phase":"PHASE2","title":"A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC","status":"ACTIVE_NOT_RECRUITING","sponsor":"Joseph J. Cullen, MD, FACS","startDate":"2018-11-16","conditions":"Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer","enrollment":43},{"nctId":"NCT07283900","phase":"PHASE2","title":"Ascorbate in Myelodysplastic Syndrome","status":"RECRUITING","sponsor":"Prajwal Dhakal","startDate":"2026-03-11","conditions":"Myelodysplastic Syndromes","enrollment":38},{"nctId":"NCT06083454","phase":"PHASE1","title":"Ascorbate With Durvalumab in Non-Small Cell Lung Cancer (NSCLC)","status":"TERMINATED","sponsor":"William Zeitler","startDate":"2023-10-23","conditions":"Non-small Cell Lung Cancer","enrollment":1},{"nctId":"NCT04150042","phase":"PHASE1","title":"SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells","status":"RECRUITING","sponsor":"General Oncology, Inc.","startDate":"2021-01-13","conditions":"Pancreatic Adenocarcinoma Metastatic, BRCA1 Mutation, BRCA2 Mutation","enrollment":24},{"nctId":"NCT02344355","phase":"PHASE2","title":"A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bryan Allen","startDate":"2017-03-13","conditions":"Glioblastoma Multiforme","enrollment":90},{"nctId":"NCT04900792","phase":"PHASE1","title":"A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bryan Allen","startDate":"2023-02-28","conditions":"Glioblastoma, Glioblastoma Multiforme","enrollment":17},{"nctId":"NCT01852890","phase":"PHASE1","title":"Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I","status":"COMPLETED","sponsor":"Joseph J. Cullen","startDate":"2014-01","conditions":"Pancreatic Neoplasms","enrollment":16},{"nctId":"NCT02966665","phase":"PHASE1","title":": Vascular Function in Health and Disease","status":"RECRUITING","sponsor":"Russell Richardson","startDate":"2008-09","conditions":"Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure","enrollment":420},{"nctId":"NCT01550510","phase":"PHASE1, PHASE2","title":"Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA","status":"TERMINATED","sponsor":"Thomas Jefferson University","startDate":"2011-12","conditions":"Stage IV Colorectal Cancer","enrollment":4},{"nctId":"NCT01555489","phase":"PHASE2","title":"Assessing the Efficacy and Safety of IV Vitamin C in Combination With Standard Chemotherapy for Pancreatic Ca","status":"TERMINATED","sponsor":"Thomas Jefferson University","startDate":"2011-10","conditions":"Stage IV Pancreatic Cancer","enrollment":11},{"nctId":"NCT01754987","phase":"PHASE1, PHASE2","title":"A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2012-09","conditions":"Metastatic Hepatocellular Carcinoma, Advanced Liver Cancer","enrollment":5},{"nctId":"NCT05274568","phase":"PHASE1","title":"Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein","status":"COMPLETED","sponsor":"Invicro","startDate":"2022-01-31","conditions":"Parkinson Disease, Multisystem Atrophy, Healthy Volunteer","enrollment":5},{"nctId":"NCT06493370","phase":"PHASE2","title":"Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer","status":"RECRUITING","sponsor":"University of Kansas Medical Center","startDate":"2025-01-16","conditions":"Bladder Cancer","enrollment":48},{"nctId":"NCT05501548","phase":"PHASE2","title":"Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer","status":"TERMINATED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","startDate":"2023-06-30","conditions":"Prostate Cancer, Castration-resistant Prostate Cancer","enrollment":4},{"nctId":"NCT01752491","phase":"PHASE1","title":"A Phase I Trial of High-Dose Ascorbate in Glioblastoma Multiforme","status":"COMPLETED","sponsor":"Joseph J. Cullen, MD, FACS","startDate":"2013-04-01","conditions":"Glioblastoma, GBM, Glioblastoma Multiforme","enrollment":13},{"nctId":"NCT04291508","phase":"PHASE2","title":"Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2021-10-13","conditions":"Acute Respiratory Distress Syndrome, Critical Illness, Respiratory Failure","enrollment":488},{"nctId":"NCT03508726","phase":"PHASE1, PHASE2","title":"High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas","status":"COMPLETED","sponsor":"Mohammed Milhem","startDate":"2019-06-27","conditions":"Soft Tissue Sarcoma","enrollment":25},{"nctId":"NCT06018896","phase":"PHASE2","title":"Vitamin C to Quality of Life in Patients With Terminal Stage Pancreatic Cancer","status":"RECRUITING","sponsor":"Fudan University","startDate":"2023-08-25","conditions":"Metastatic Pancreatic Cancer, Terminal Cancer","enrollment":20},{"nctId":"NCT03433781","phase":"PHASE1, PHASE2","title":"A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2018-05-01","conditions":"Myelodysplastic Syndromes","enrollment":4},{"nctId":"NCT05215743","phase":"PHASE1","title":"Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study.","status":"COMPLETED","sponsor":"University of Chile","startDate":"2022-08-09","conditions":"Acute Myocardial Infarction, Ischemia-reperfusion Injury, Reperfusion Injury, Myocardial","enrollment":18},{"nctId":"NCT05327348","phase":"PHASE3","title":"Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery","status":"UNKNOWN","sponsor":"University of Malaya","startDate":"2022-09-25","conditions":"Oxidative Stress, Ischemia-reperfusion Injury","enrollment":34},{"nctId":"NCT04796636","phase":"PHASE1","title":"High-dose Intravenous Vitamin C in Patients With Septic Shock","status":"UNKNOWN","sponsor":"Melbourne Health","startDate":"2021-09-27","conditions":"Sepsis, Severe, Septic Shock","enrollment":30},{"nctId":"NCT03964688","phase":"PHASE2","title":"Effect of Vitamin C in Autologous Stem Cell Transplantations","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2019-12-10","conditions":"Myeloma Multiple, Lymphoma","enrollment":47},{"nctId":"NCT04999137","phase":"PHASE2","title":"Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa","status":"UNKNOWN","sponsor":"Liverpool School of Tropical Medicine","startDate":"2021-09-01","conditions":"Sepsis, Septic Shock, HIV","enrollment":60},{"nctId":"NCT04395768","phase":"PHASE2","title":"International ALLIANCE Study of Therapies to Prevent Progression of COVID-19","status":"UNKNOWN","sponsor":"National Institute of Integrative Medicine, Australia","startDate":"2020-09-09","conditions":"COVID19","enrollment":200},{"nctId":"NCT03799094","phase":"PHASE1, PHASE2","title":"Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations","status":"UNKNOWN","sponsor":"Clifford Hospital, Guangzhou, China","startDate":"2018-12-05","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":150},{"nctId":"NCT01364805","phase":"PHASE1","title":"New Treatment Option for Pancreatic Cancer","status":"COMPLETED","sponsor":"Jeanne Drisko, MD, CNS, FACN","startDate":"2011-04","conditions":"Pancreatic Cancer","enrollment":14},{"nctId":"NCT00228319","phase":"PHASE1, PHASE2","title":"Treatment of Newly Diagnosed Ovarian Cancer With Antioxidants","status":"COMPLETED","sponsor":"Jeanne Drisko, MD, CNS, FACN","startDate":"2002-10","conditions":"Ovarian Cancer","enrollment":27},{"nctId":"NCT01515046","phase":"PHASE2","title":"Clinical Trial of High-dose Vitamin C for Advanced Pancreatic Cancer","status":"TERMINATED","sponsor":"Joseph J. Cullen","startDate":"2012-09","conditions":"Pancreatic Neoplasms, Pancreatic Cancer","enrollment":1},{"nctId":"NCT02780505","phase":"PHASE4","title":"Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysis","status":"COMPLETED","sponsor":"Shiraz University of Medical Sciences","startDate":"2011-11","conditions":"Anemia","enrollment":66},{"nctId":"NCT01833351","phase":"PHASE1","title":"Evaluation of Intravenous Ascorbic Acid","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2011-05","conditions":"Safety and Pharmacokinetics of Intravenous Ascorbate","enrollment":34},{"nctId":"NCT01080352","phase":"PHASE2","title":"Vitamin C as an Anti-cancer Drug","status":"COMPLETED","sponsor":"Copenhagen University Hospital at Herlev","startDate":"2010-11","conditions":"Prostatic Neoplasms","enrollment":31}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ascorbic Acid Injection"],"phase":"phase_3","status":"active","brandName":"Intravenous Ascorbate","genericName":"Intravenous Ascorbate","companyName":"University of Malaya","companyId":"university-of-malaya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous ascorbate (vitamin C) acts as a pro-oxidant at high concentrations to generate reactive oxygen species that selectively kill cancer cells while supporting immune function. Used for Advanced or metastatic cancer (various solid tumors), Cancer adjunctive therapy in combination with conventional chemotherapy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}