{"id":"intravenous-antibiotic","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intravenous antibiotics work through various mechanisms depending on the specific agent—commonly by inhibiting bacterial protein synthesis (e.g., aminoglycosides, tetracyclines), disrupting cell wall integrity (e.g., beta-lactams), or interfering with nucleic acid synthesis. The George Institute's Phase 3 candidate likely targets a specific bacterial pathogen or resistance mechanism relevant to serious infections requiring parenteral administration.","oneSentence":"An intravenous antibiotic that inhibits bacterial protein synthesis or cell wall formation to treat infections.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:48:42.015Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT07496008","phase":"","title":"Individualized Precision Isavuconazole Therapy Guided by PK/PD Principles for the Geriatric Population","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-03-25","conditions":"Isavuconazole, Invasion Pulmonary Mycosis","enrollment":150},{"nctId":"NCT07495150","phase":"NA","title":"Intracalvariosseous Plus Intravenous Antibiotics for Moderate-to-Severe Bacterial Meningitis","status":"NOT_YET_RECRUITING","sponsor":"yilong Wang","startDate":"2026-04-01","conditions":"Blood-Brain Barrier, Bacterial Meningitis","enrollment":86},{"nctId":"NCT07494981","phase":"","title":"Individualized Precision Therapy With Ceftazidime and Avibactam Guided by PK/PD in Geriatric Populations","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-03-25","conditions":"Ceftazidime-avibactam","enrollment":150},{"nctId":"NCT05023200","phase":"","title":"The Personalised Antibiotic Duration for Cellulitis (PAD-C) Study","status":"COMPLETED","sponsor":"University of Sussex","startDate":"2021-06-09","conditions":"Cellulitis, Cellulitis of Leg, Antibiotic Duration","enrollment":230},{"nctId":"NCT07492771","phase":"PHASE1","title":"MP101 in Adults With Acute Pseudomonas Aeruginosa Pneumonia","status":"NOT_YET_RECRUITING","sponsor":"MicrobiotiX Co., Ltd","startDate":"2026-03","conditions":"Pneumonia - Bacterial, Pseudomonas Aeruginosa Infection","enrollment":18},{"nctId":"NCT07184866","phase":"NA","title":"Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2026-04","conditions":"Acute-on-Chronic Liver Failure (ACLF)","enrollment":110},{"nctId":"NCT05447559","phase":"PHASE4","title":"Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study","status":"RECRUITING","sponsor":"Monash University","startDate":"2023-02-07","conditions":"Surgical Site Infection","enrollment":9180},{"nctId":"NCT06748144","phase":"PHASE2, PHASE3","title":"IO Vancomycin Spine","status":"NOT_YET_RECRUITING","sponsor":"The Methodist Hospital Research Institute","startDate":"2026-05","conditions":"Lumbar Fusion Surgery","enrollment":30},{"nctId":"NCT07492888","phase":"PHASE2","title":"Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)","status":"NOT_YET_RECRUITING","sponsor":"ImmunityBio, Inc.","startDate":"2026-04-15","conditions":"Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum, Sepsis","enrollment":20},{"nctId":"NCT07489274","phase":"PHASE4","title":"Adjunctive Hyperbaric Oxygen Treatment for Patients With Necrotizing Soft-Tissue Infection (HOT-NSTI Trial). 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