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These mechanisms collectively suppress cortical activity and consciousness within seconds of administration.","oneSentence":"Intravenous anesthetics work by enhancing inhibitory GABAergic neurotransmission and/or blocking excitatory glutamatergic signaling in the central nervous system to produce rapid unconsciousness.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:33.678Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia"},{"name":"Sedation in intensive care units"}]},"trialDetails":[{"nctId":"NCT06867068","phase":"PHASE1","title":"Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery","status":"COMPLETED","sponsor":"Albert Einstein College of Medicine","startDate":"2016-10-04","conditions":"Anesthesia, Tooth Extraction","enrollment":73},{"nctId":"NCT07357480","phase":"NA","title":"Comparison of Target-Controlled and Manual Total Intravenous Anesthesia 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