{"id":"intravenous-acetazolamide","safety":{"commonSideEffects":[{"rate":"10-50","effect":"Paresthesia (tingling in extremities)"},{"rate":"variable","effect":"Metabolic acidosis"},{"rate":"variable","effect":"Hypokalemia"},{"rate":"5-10","effect":"Altered taste (dysgeusia)"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL20","moleculeType":"Small molecule","molecularWeight":"222.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetazolamide is a carbonic anhydrase inhibitor that decreases the conversion of carbon dioxide and water to bicarbonate and hydrogen ions in the proximal tubule of the kidney. This leads to increased urinary bicarbonate, sodium, and potassium excretion, resulting in mild diuresis and metabolic acidosis. The drug also reduces aqueous humor production in the eye and has effects on the central nervous system that may reduce periodic breathing.","oneSentence":"Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:23.428Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Glaucoma and ocular hypertension"},{"name":"Acute mountain sickness"},{"name":"Periodic breathing and sleep apnea"},{"name":"Idiopathic intracranial hypertension"}]},"trialDetails":[{"nctId":"NCT07469722","phase":"PHASE2, PHASE3","title":"POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure","status":"NOT_YET_RECRUITING","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2026-03-23","conditions":"Acute Heart Failure (AHF), Congestive Heart Failure Acute, Diuretic 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blockAde In Acute Heart Failure","status":"UNKNOWN","sponsor":"University of Parma","startDate":"2019-12-01","conditions":"Acute Heart Failure","enrollment":206},{"nctId":"NCT01973335","phase":"PHASE4","title":"Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure","status":"COMPLETED","sponsor":"Hasselt University","startDate":"2013-11","conditions":"Heart Failure","enrollment":34},{"nctId":"NCT03720288","phase":"PHASE3","title":"Acetazolamide in Patients With Acute Heart Failure","status":"UNKNOWN","sponsor":"University of Sao Paulo General Hospital","startDate":"2018-10-01","conditions":"Heart Failure, Acute Heart Failure","enrollment":90},{"nctId":"NCT01851473","phase":"PHASE1","title":"Interactions Between Intravenous Cocaine and Acetazolamide or Quinine","status":"COMPLETED","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2012-10-24","conditions":"Cocaine Use, Pharmacokinetics","enrollment":14},{"nctId":"NCT02824406","phase":"","title":"Cerebrovascular Reserve Measurements in Sickle Cell Disease","status":"UNKNOWN","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2014-08","conditions":"Sickle Cell Disease","enrollment":60},{"nctId":"NCT02142712","phase":"PHASE2","title":"Histamine Glutamate Antagonism in Stroke","status":"COMPLETED","sponsor":"University of Florida","startDate":"2014-12","conditions":"Acute Cerebrovascular Accident, Cerebral Edema","enrollment":3},{"nctId":"NCT01146288","phase":"NA","title":"Effect of Acetazolamide and Furosemide on Obesity-induced Glomerular Hyperfiltration","status":"COMPLETED","sponsor":"Rabin Medical Center","startDate":"2010-07","conditions":"Obesity-induced Hyperfiltration","enrollment":13},{"nctId":"NCT01889498","phase":"PHASE4","title":"Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery","status":"UNKNOWN","sponsor":"Liverpool Heart and Chest Hospital NHS Foundation Trust","startDate":"2014-07","conditions":"Thoracic Aneurysm","enrollment":100},{"nctId":"NCT02140450","phase":"NA","title":"Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection","status":"COMPLETED","sponsor":"Mashhad University of Medical Sciences","startDate":"2012-02","conditions":"Intraocular Pressure Change in Intravitreal Injection","enrollment":70},{"nctId":"NCT00982176","phase":"","title":"Determinants of Cognitive Impairment After Acute Coronary Syndrome","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2009-09","conditions":"Coronary Syndrome","enrollment":49},{"nctId":"NCT00485238","phase":"PHASE4","title":"ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function","status":"UNKNOWN","sponsor":"National University Hospital, Singapore","startDate":"2007-02","conditions":"Glaucoma","enrollment":60},{"nctId":"NCT00637468","phase":"PHASE3","title":"EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye","status":"TERMINATED","sponsor":"University Hospital Freiburg","startDate":"2002-09","conditions":"Retinal Artery Occlusion, Fibrinolysis, Visual Acuity","enrollment":84}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":101,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intravenous acetazolamide","genericName":"Intravenous acetazolamide","companyName":"National University Hospital, Singapore","companyId":"national-university-hospital-singapore","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Acetazolamide inhibits carbonic anhydrase, reducing bicarbonate reabsorption in the kidney and promoting diuresis and alkalinization of urine. Used for Glaucoma and ocular hypertension, Acute mountain sickness, Periodic breathing and sleep apnea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}