{"id":"intrauterine-misoprostol","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine contractions/cramping"},{"rate":null,"effect":"Vaginal bleeding"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Chills"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol binds to prostaglandin receptors on uterine smooth muscle, increasing intracellular calcium and triggering myometrial contractions. 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University","startDate":"2019-09-10","conditions":"IUD Insertion Complication","enrollment":129},{"nctId":"NCT03723031","phase":"PHASE2","title":"Intrauterine Misoprostol Versus Rectal Misoprostol in Reducing Blood Loss During Cesarean Section","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2018-11-15","conditions":"Hemorrhage, Postpartum","enrollment":98},{"nctId":"NCT04080349","phase":"PHASE4","title":"Comparison of Vaginal Misoprostol and Dinoprostone Prior to Copper Intrauterine Device Insertion in Women Delivered Only by Cesarean Delivery","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-09-10","conditions":"IUD Pain","enrollment":300},{"nctId":"NCT03790371","phase":"PHASE3","title":"Vaginal Misoprostol Before Intrauterine Contraceptive Device Insertion","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2015-10-01","conditions":"Contraception","enrollment":90},{"nctId":"NCT03587077","phase":"NA","title":"Pain Relief During IUD 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PHASE3","title":"Comparison Between 2 Doses of Misoprostol Before Intrauterine Device","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-09","conditions":"Pain Relief","enrollment":212},{"nctId":"NCT02522130","phase":"NA","title":"Different Analgesics Prior to Intrauterine Device (IUD) Insertion: Is There Any Evidence?","status":"UNKNOWN","sponsor":"Al Hayat National Hospital","startDate":"2015-07","conditions":"IUD Insertion Complication","enrollment":200},{"nctId":"NCT02412033","phase":"PHASE1","title":"Misoprostol Prior to Intrauterine Contraceptive Device Insertion","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-03","conditions":"Pain Prior to IUD Insertion","enrollment":140},{"nctId":"NCT01307111","phase":"NA","title":"Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women","status":"COMPLETED","sponsor":"University of New 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