{"id":"intrathecal-morphine-sufentanil","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Catheter-related complications"}]},"_chembl":{"chemblId":"CHEMBL1201163","moleculeType":"Small molecule","molecularWeight":"578.68"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both morphine and sufentanil are mu-opioid receptor agonists administered directly into the cerebrospinal fluid via intrathecal injection. This direct spinal delivery allows for high local concentrations at opioid receptors in the dorsal horn of the spinal cord, producing potent analgesia at much lower systemic doses than oral or intravenous administration. Sufentanil is significantly more potent than morphine, requiring smaller doses for equivalent analgesic effect.","oneSentence":"Intrathecal morphine and sufentanil are opioid agonists that bind to opioid receptors in the spinal cord to block pain signal transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:40.829Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain management via intrathecal infusion"},{"name":"Cancer pain"},{"name":"Post-operative pain"}]},"trialDetails":[{"nctId":"NCT07377630","phase":"PHASE4","title":"Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Istituto Giannina Gaslini","startDate":"2026-03-01","conditions":"Pregnancy, Cesarean Section, Neuroaxial Analgesia Procedures","enrollment":100},{"nctId":"NCT05233462","phase":"NA","title":"Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia","status":"RECRUITING","sponsor":"University Hospital, Caen","startDate":"2022-02-23","conditions":"Regional Anesthesia Morbidity, Cesarean Section Complications, Local Anesthetic Complication","enrollment":250},{"nctId":"NCT04755712","phase":"PHASE4","title":"Comparison of Two Analgesic Strategies After Scheduled Caesarean","status":"COMPLETED","sponsor":"GCS Ramsay Santé pour l'Enseignement et la Recherche","startDate":"2021-03-22","conditions":"Analgesia","enrollment":104},{"nctId":"NCT05042817","phase":"NA","title":"Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery","status":"COMPLETED","sponsor":"University of Liege","startDate":"2021-10-01","conditions":"Analgesia","enrollment":56},{"nctId":"NCT02666794","phase":"NA","title":"Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2017-07-12","conditions":"Fetal Bradycardia, Hypertonic Uterine, Catecholamines","enrollment":50},{"nctId":"NCT03036384","phase":"PHASE2","title":"Estimation of the ED95 of Intrathecal Hyperbaric Prilocaine 2% With Sufentanyl for Scheduled Cesarean Delivery","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2016-03","conditions":"Pregnant Women","enrollment":40},{"nctId":"NCT03007121","phase":"PHASE4","title":"Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.","status":"COMPLETED","sponsor":"Charles University, Czech Republic","startDate":"2017-04-10","conditions":"Analgesia, Patient-Controlled, Epidural Analgesia, Anesthesia; Spinal","enrollment":75},{"nctId":"NCT03428880","phase":"PHASE4","title":"Ultrasound Guided QLB III Versus Intrathecal Morphine for Analgesia After Cesarean Section","status":"COMPLETED","sponsor":"University Tunis El Manar","startDate":"2017-02-15","conditions":"Block","enrollment":120},{"nctId":"NCT02793843","phase":"NA","title":"Ondansetron vs Ondansetron Plus Dexamethasone for Relieving Intrathecal Morphine Side Effects After C-section","status":"COMPLETED","sponsor":"Makassed General Hospital","startDate":"2016-06","conditions":"Pruritus, Cesarean Section","enrollment":194},{"nctId":"NCT02711072","phase":"NA","title":"Continuous Infusion for Pain Relief","status":"UNKNOWN","sponsor":"Tunisian Military Hospital","startDate":"2016-03","conditions":"Regional Anesthesia, Caeserian Section, Local Anesthetic","enrollment":60},{"nctId":"NCT02152514","phase":"PHASE4","title":"RCT Comparing Analgesia Post-VATS With Epimorph VS Placebo","status":"TERMINATED","sponsor":"Université de Sherbrooke","startDate":"2013-04","conditions":"Thoracic Surgery, Video-assisted, Postoperative Pain, Rachianesthesia","enrollment":34},{"nctId":"NCT02279628","phase":"PHASE4","title":"Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section","status":"UNKNOWN","sponsor":"Central Hospital, Nancy, France","startDate":"2014-07","conditions":"Postoperative Pain","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intrathecal Morphine/Sufentanil","genericName":"Intrathecal Morphine/Sufentanil","companyName":"Université de Sherbrooke","companyId":"universit-de-sherbrooke","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intrathecal morphine and sufentanil are opioid agonists that bind to opioid receptors in the spinal cord to block pain signal transmission. Used for Chronic pain management via intrathecal infusion, Cancer pain, Post-operative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}