{"id":"intrastromal-voriconazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Corneal inflammation"},{"rate":null,"effect":"Anterior chamber reaction"},{"rate":null,"effect":"Corneal edema"},{"rate":null,"effect":"Pain or discomfort at injection site"}]},"_chembl":{"chemblId":"CHEMBL638","moleculeType":"Small molecule","molecularWeight":"349.32"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Voriconazole is a triazole antifungal that inhibits lanosterol 14α-demethylase, a key enzyme in fungal ergosterol synthesis, disrupting the fungal cell membrane. When administered intrastromally (directly into corneal tissue), it achieves high local concentrations to treat corneal fungal infections that are difficult to penetrate with topical or systemic administration.","oneSentence":"Intrastromal voriconazole is an antifungal agent delivered directly into the corneal stroma to treat fungal keratitis by inhibiting fungal cell wall synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:41.629Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal keratitis (corneal fungal infection)"}]},"trialDetails":[{"nctId":"NCT02731638","phase":"PHASE3","title":"Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-09","conditions":"Corneal Ulcer, Fungal Keratitis","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":47,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intrastromal voriconazole","genericName":"Intrastromal voriconazole","companyName":"University of California, San Francisco","companyId":"university-of-california-san-francisco","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intrastromal voriconazole is an antifungal agent delivered directly into the corneal stroma to treat fungal keratitis by inhibiting fungal cell wall synthesis. Used for Fungal keratitis (corneal fungal infection).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}