{"id":"intraperitoneal-nebulisation-of-magnesium-sulphate","safety":{"commonSideEffects":[{"rate":null,"effect":"Local peritoneal irritation"},{"rate":null,"effect":"Hypermagnesemia (if systemic absorption occurs)"}]},"_chembl":{"chemblId":"CHEMBL3544802","moleculeType":"Small molecule","molecularWeight":"231.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium acts as a natural NMDA receptor antagonist and has anti-inflammatory properties when applied locally to peritoneal tissues. Intraperitoneal nebulisation delivers the agent directly to visceral structures, potentially reducing postoperative pain, adhesion formation, and inflammatory responses in the peritoneal cavity without systemic absorption.","oneSentence":"Magnesium sulphate delivered intraperitoneally reduces visceral pain and inflammation through local anti-inflammatory effects and modulation of nociceptive pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:49:39.228Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative visceral pain management"},{"name":"Prevention of peritoneal adhesions"}]},"trialDetails":[{"nctId":"NCT01542697","phase":"PHASE4","title":"Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy","status":"UNKNOWN","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2011-06","conditions":"Postoperative Pain","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"intraperitoneal nebulisation of magnesium sulphate","genericName":"intraperitoneal nebulisation of magnesium sulphate","companyName":"B.P. Koirala Institute of Health Sciences","companyId":"b-p-koirala-institute-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magnesium sulphate delivered intraperitoneally reduces visceral pain and inflammation through local anti-inflammatory effects and modulation of nociceptive pathways. Used for Postoperative visceral pain management, Prevention of peritoneal adhesions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}