{"id":"intraoperative-intraosseous-vancomycin","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation or inflammation at injection site"},{"rate":null,"effect":"Systemic hypersensitivity reactions (rare with local administration)"}]},"_chembl":{"chemblId":"CHEMBL262777","moleculeType":"Small molecule","molecularWeight":"1449.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vancomycin works by preventing cross-linking of peptidoglycan strands in bacterial cell walls, leading to cell wall instability and bacterial death. When administered intraoperatively as an intraosseous injection directly into bone, it achieves high local concentrations at the surgical site to prevent infection during orthopedic procedures. This local delivery approach minimizes systemic exposure while maximizing antimicrobial efficacy at the site of greatest infection risk.","oneSentence":"Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala peptidoglycan precursors, delivered intraoperatively into bone to prevent surgical site infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:39.273Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis in orthopedic procedures"}]},"trialDetails":[{"nctId":"NCT03713528","phase":"PHASE4","title":"Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?","status":"ENROLLING_BY_INVITATION","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2020-01-14","conditions":"Joint Infection","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vancomycin"],"phase":"marketed","status":"active","brandName":"Intraoperative Intraosseous Vancomycin","genericName":"Intraoperative Intraosseous Vancomycin","companyName":"OrthoCarolina Research Institute, Inc.","companyId":"orthocarolina-research-institute-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vancomycin is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala peptidoglycan precursors, delivered intraoperatively into bone to prevent surgical site infections. Used for Surgical site infection prophylaxis in orthopedic procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}