{"id":"intranasal-influenza-live-attenuated-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal congestion"},{"rate":null,"effect":"Runny nose"},{"rate":null,"effect":"Sore throat"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains temperature-sensitive, attenuated influenza virus strains that replicate in the cooler upper respiratory tract but are unable to cause disease. This replication triggers both mucosal IgA antibodies and systemic cellular and humoral immune responses, providing protection against circulating influenza viruses. The intranasal route mimics natural infection and generates broader, more durable immunity compared to inactivated vaccines.","oneSentence":"This live attenuated influenza vaccine stimulates immune responses by delivering weakened influenza virus strains intranasally to induce mucosal and systemic immunity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:38.891Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Influenza prevention in children and adults"}]},"trialDetails":[{"nctId":"NCT04164212","phase":"PHASE4","title":"Live Attenuated Influenza Vaccine as a Nasal Model for Influenza Infection","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2020-09-01","conditions":"Influenza","enrollment":33},{"nctId":"NCT02597647","phase":"PHASE1","title":"Bacterial Composition and Immune Responses in the Nose and Oropharynx During Influenza Infection","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2011-02","conditions":"Influenza","enrollment":17},{"nctId":"NCT07093281","phase":"PHASE4","title":"Intranasal LAIV Mucosal Immunity Examination","status":"NOT_YET_RECRUITING","sponsor":"University of Maryland, Baltimore","startDate":"2026-02","conditions":"Impact of Vaccination","enrollment":25},{"nctId":"NCT07232745","phase":"PHASE4","title":"Mucosal and Systemic Immune Responses Induced by an Intranasal Influenza Live Attenuated Vaccine","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jiangsu Province Centers for Disease Control and Prevention","startDate":"2025-10-12","conditions":"Influenza","enrollment":60},{"nctId":"NCT07177417","phase":"PHASE4","title":"Characterizing the Human Airway Immune Response to FluMist Vaccination","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2025-09-09","conditions":"Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response","enrollment":30},{"nctId":"NCT04960397","phase":"PHASE1","title":"Assess the Safety and Immunogenicity of One or Two Doses of Sing2016 M2SR H3N2 Influenza Vaccine","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2021-09-10","conditions":"H3N2 Influenza","enrollment":140},{"nctId":"NCT06620185","phase":"NA","title":"GEneRating Mucosal Immunity After INfluenzA Infection and Vaccination in Lung and Lymphoid TissuE","status":"RECRUITING","sponsor":"Imperial College London","startDate":"2025-04-16","conditions":"Influenza","enrollment":36},{"nctId":"NCT06609811","phase":"PHASE4","title":"The Interaction Between Mucosal Microbiota Colonization and the Immune Response to an Intranasal Influenza Live Attenuated Vaccine","status":"COMPLETED","sponsor":"Jiangsu Province Centers for Disease Control and Prevention","startDate":"2024-09-21","conditions":"Influenza","enrollment":200},{"nctId":"NCT05290792","phase":"NA","title":"Use of Wearable Sensors for Early Detection and Tracking of Viral Respiratory Tract Infections","status":"COMPLETED","sponsor":"Emily McDonald","startDate":"2021-12-10","conditions":"Viral Respiratory Tract Infection, Influenza","enrollment":56},{"nctId":"NCT03898986","phase":"PHASE1","title":"The Effects of Attenuated Versus Inactivated Flu Vaccine in Twin Sets","status":"COMPLETED","sponsor":"Stanford University","startDate":"2019-10-08","conditions":"Influenza","enrollment":18},{"nctId":"NCT01866540","phase":"NA","title":"Immune Response To Intranasal Influenza Vaccination","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Bergen","startDate":"2012-10-01","conditions":"Tonsillitis, Hypertrophy","enrollment":300},{"nctId":"NCT03884296","phase":"PHASE4","title":"Response to Live Attenuated Influenza Vaccine in Tonsillar Tissues and Blood","status":"WITHDRAWN","sponsor":"Stanford University","startDate":"2019-04-15","conditions":"Influenza","enrollment":""},{"nctId":"NCT04110366","phase":"NA","title":"Nasal and Systemic Immune Responses to Nasal Influenza Vaccine","status":"COMPLETED","sponsor":"Imperial College Healthcare NHS Trust","startDate":"2018-06-14","conditions":"Influenza, Vaccine Virus Shedding","enrollment":48},{"nctId":"NCT03023683","phase":"PHASE4","title":"Protective Mechanisms Against a Pandemic Respiratory Virus (SLVP024)","status":"COMPLETED","sponsor":"Stanford University","startDate":"2012-10","conditions":"Influenza","enrollment":18},{"nctId":"NCT03020472","phase":"PHASE4","title":"Kinetics of B-Cell Responses to Live, Attenuated Influenza Vaccine (LAIV) in Young Children Two Years of Age","status":"TERMINATED","sponsor":"Stanford University","startDate":"2008-11","conditions":"Influenza","enrollment":6},{"nctId":"NCT00461981","phase":"PHASE2","title":"A Phase 2 Study to Evaluate Immune Responses of FluMist®","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2007-05","conditions":"Influenza Vaccine","enrollment":101},{"nctId":"NCT03600428","phase":"PHASE4","title":"Safety of LAIV4 in Children With Asthma","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2018-10-15","conditions":"Asthma in Children, Vaccine Adverse Reaction, Vaccine Reaction","enrollment":152},{"nctId":"NCT04146623","phase":"PHASE1","title":"Safety Study of Live Attenuated Influenza Vaccine, CodaVax, Delivered Via Intranasal Spray","status":"COMPLETED","sponsor":"Codagenix, Inc","startDate":"2019-05-07","conditions":"Influenza","enrollment":33},{"nctId":"NCT02111512","phase":"PHASE4","title":"Safety of Nasal Influenza Immunisation in Egg Allergic Children - The SNIFFLE 2 Study","status":"COMPLETED","sponsor":"University Hospital Southampton NHS Foundation Trust","startDate":"2014-09","conditions":"Egg Hypersensitivity","enrollment":779},{"nctId":"NCT03926416","phase":"PHASE1","title":"Safety Study of Live Attenuated Influenza Vaccine, CodaVax","status":"COMPLETED","sponsor":"Codagenix, Inc","startDate":"2017-02-21","conditions":"Influenza","enrollment":125},{"nctId":"NCT02972957","phase":"PHASE4","title":"A Study of Intranasal Live Attenuated Influenza Vaccine Immunogenicity and Associations With the Nasopharyngeal Microbiome Among Children in the Gambia","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2017-01-30","conditions":"Influenza","enrollment":364},{"nctId":"NCT03453801","phase":"PHASE1","title":"The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection","status":"COMPLETED","sponsor":"Stanford University","startDate":"2014-09-30","conditions":"Influenza, Healthy","enrollment":80},{"nctId":"NCT03088904","phase":"PHASE1","title":"Genetic and Environmental Factors in the Response to Influenza Vaccination","status":"COMPLETED","sponsor":"Stanford University","startDate":"2014-10-03","conditions":"Influenza, Healthy","enrollment":109},{"nctId":"NCT02251288","phase":"PHASE1","title":"A Phase I Study Priming With an Inactivated A/H7N9 Influenza Virus Vaccine With or Without MF59 Adjuvant Followed by Live Attenuated A/H7N9 Influenza Virus Vaccine","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2015-05-18","conditions":"Avian Influenza, Immunisation","enrollment":62},{"nctId":"NCT01511419","phase":"PHASE1","title":"Safety Trial of Live Attenuated Influenza (H7N3) Vaccine","status":"COMPLETED","sponsor":"PATH","startDate":"2012-04","conditions":"Influenza, Avian Influenza","enrollment":40},{"nctId":"NCT03028974","phase":"PHASE4","title":"Innate and Acquired Immunity to Influenza Infection and Immunization (SLVP029)","status":"COMPLETED","sponsor":"Stanford University","startDate":"2014-09-17","conditions":"Influenza","enrollment":77},{"nctId":"NCT03020498","phase":"PHASE4","title":"B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011)","status":"COMPLETED","sponsor":"Stanford University","startDate":"2010-09","conditions":"Influenza","enrollment":91},{"nctId":"NCT01841918","phase":"PHASE2","title":"Safety and Immunogenicity of Live Attenuated Influenza H5N2","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2013-01","conditions":"Influenza Due to Influenza A Virus Subtype H5N2","enrollment":150},{"nctId":"NCT00538512","phase":"PHASE4","title":"Comparative Study of Influenza Vaccines in Adults, FLUVACS-year 4","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2007-09","conditions":"Influenza","enrollment":1952},{"nctId":"NCT02950688","phase":"PHASE1","title":"Safety and Effectiveness of a Seasonal Live Attenuated Influenza Vaccine in a Human Challenge Model of Infection With Wild-type (wt) Influenza A/California/2009 (H1N1)-Like Virus","status":"WITHDRAWN","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"","conditions":"Influenza, Human","enrollment":""},{"nctId":"NCT02474901","phase":"PHASE2","title":"Shedding, Immunogenicity and Safety of Quadrivalent Live Intranasal Influenza Vaccine (QLAIV) in HIV-infected Children and Young Adults","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2013-07","conditions":"Human Immunodeficiency Virus (HIV)","enrollment":101},{"nctId":"NCT03028987","phase":"PHASE4","title":"Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection (SLVP031)","status":"TERMINATED","sponsor":"Stanford University","startDate":"2014-11-19","conditions":"Influenza","enrollment":10},{"nctId":"NCT00344305","phase":"PHASE2","title":"A Study to Evaluate the Shedding and Safety of Trivalent Influenza Virus Vaccine Live, Intranasal in Infants and Young Children","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2006-05-01","conditions":"Healthy","enrollment":200},{"nctId":"NCT03022435","phase":"PHASE4","title":"T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 4, 2012","status":"COMPLETED","sponsor":"Stanford University","startDate":"2012-10","conditions":"Influenza","enrollment":22},{"nctId":"NCT01987349","phase":"PHASE4","title":"T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009","status":"COMPLETED","sponsor":"Stanford University","startDate":"2009-09","conditions":"Influenza","enrollment":72},{"nctId":"NCT03023709","phase":"PHASE4","title":"Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032)","status":"TERMINATED","sponsor":"Stanford University","startDate":"2015-09","conditions":"Influenza","enrollment":3},{"nctId":"NCT03023553","phase":"PHASE4","title":"The Human Mucosal Immune Responses to Influenza Virus (SLVP026)","status":"COMPLETED","sponsor":"Stanford University","startDate":"2012-12","conditions":"Influenza","enrollment":13},{"nctId":"NCT01545349","phase":"PHASE1","title":"Safety of Lactobacillus Rhamnosus GG Versus Placebo in Elderly Subjects Receiving Live Attenuated Influenza Vaccine","status":"COMPLETED","sponsor":"Patricia L. Hibberd","startDate":"2012-02","conditions":"Healthy, Influenza","enrollment":30},{"nctId":"NCT02665871","phase":"PHASE1","title":"Safety Study of Freeze-dried Live Attenuated Influenza Vaccine for Intranasal Administration in Chinese Adults Aged 3 Years and Older","status":"UNKNOWN","sponsor":"Beijing Chaoyang District Centre for Disease Control and Prevention","startDate":"2016-03","conditions":"Influenza","enrollment":80},{"nctId":"NCT01055184","phase":"PHASE1, PHASE2","title":"Effects of Age on Response to the 2009 H1N1 Virus Vaccine","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2010-03","conditions":"2009 H1N1 Influenza Virus","enrollment":34},{"nctId":"NCT01023776","phase":"PHASE4","title":"Infectivity, Replication & Immunogenicity of Live nH1N1 Vaccine","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2009-11","conditions":"Influenza","enrollment":20},{"nctId":"NCT01097941","phase":"PHASE4","title":"Effect of Age and Prior Immunity on Response to H1N1 Vaccines in Children","status":"WITHDRAWN","sponsor":"University of Rochester","startDate":"2010-03","conditions":"2009 H1N1 Influenza","enrollment":""},{"nctId":"NCT01625689","phase":"PHASE2","title":"Safety and Immunogenicity of a Single Dose of Intranasal Seasonal Trivalent Live-Attenuated Influenza Vaccine","status":"COMPLETED","sponsor":"PATH Vaccine Solutions","startDate":"2012-06","conditions":"Influenza","enrollment":309},{"nctId":"NCT01181323","phase":"PHASE2","title":"Post-Partum Immunization With Live Attenuated Influenza Vaccine (LAIV) or Trivalent Influenza Vaccine (TIV) in Post-Partum Breast Feeding Women","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2011-09","conditions":"Influenza","enrollment":240},{"nctId":"NCT00133523","phase":"PHASE4","title":"FLU-VACS Comparative Study in Adults","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2004-10","conditions":"Influenza","enrollment":2349},{"nctId":"NCT01369862","phase":"PHASE1, PHASE2","title":"Study of Single Dose GHB16L2 Trivalent Influenza Vaccine in Healthy Adults","status":"COMPLETED","sponsor":"AVIR Green Hills Biotechnology AG","startDate":"2011-01","conditions":"Influenza, Human","enrollment":80},{"nctId":"NCT01044095","phase":"NA","title":"Study of Seasonal Influenza Vaccine Against H5N1 Avian Influenza Virus","status":"COMPLETED","sponsor":"Armed Forces Research Institute of Medical Sciences, Thailand","startDate":"2009-11","conditions":"Influenza","enrollment":26},{"nctId":"NCT00113880","phase":"","title":"A Study to Evaluate the Safety of FluMist in Healthy Children and Healthy Adults","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2003-10","conditions":"Healthy","enrollment":63061},{"nctId":"NCT00192309","phase":"PHASE2","title":"Phase II Study to Investigate the Kinetics of the Immune Response Generated by Influenza Virus Vaccine.","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2001-09","conditions":"Influenza","enrollment":31},{"nctId":"NCT00224783","phase":"PHASE1","title":"Phase I Trial Evaluating Safety and Tolerability of CAIV-T in Healthy Japanese Male Adults","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2002-08","conditions":"Healthy Japanese Male Adults","enrollment":45},{"nctId":"NCT00906750","phase":"PHASE1","title":"A Study of a Live Intranasal Influenza Vaccine in Children With Cancer","status":"COMPLETED","sponsor":"St. Jude Children's Research Hospital","startDate":"2008-10","conditions":"Cancer","enrollment":56},{"nctId":"NCT01091246","phase":"PHASE3","title":"A Study to Evaluate the Immunogenicity of Quadrivalent Live Attenuated Influenza Vaccine (LAIV) in Children","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2010-03","conditions":"Healthy or Stable Chronic Illness","enrollment":2312},{"nctId":"NCT00945893","phase":"PHASE4","title":"A Study to Evaluate the Safety of H1N1 Monovalent Vaccine (MEDI3414) in Healthy Adults","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2009-08","conditions":"Healthy","enrollment":300},{"nctId":"NCT00946101","phase":"PHASE4","title":"A Study to Evaluate the Safety of HIN1 Monovalent Vaccine (MEDI3414) in Children 2 to 17 Years of Age","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2009-08","conditions":"Influenza","enrollment":326},{"nctId":"NCT00620412","phase":"PHASE1","title":"Probiotics to Enhance Immunogenicity of Influenza Vaccine in Healthy Adults","status":"COMPLETED","sponsor":"Tufts Medical Center","startDate":"2007-09","conditions":"Healthy","enrollment":52},{"nctId":"NCT01078701","phase":"PHASE2","title":"Dose Finding Study of Single Dose GHB11L1 in Healthy Adults","status":"COMPLETED","sponsor":"AVIR Green Hills Biotechnology AG","startDate":"2009-12","conditions":"Influenza, Human","enrollment":49},{"nctId":"NCT00724997","phase":"PHASE1","title":"Randomized, Double-blind, Placebo-controlled, Phase I Dose-escalation Study of Single Dose GHB01L1 in Healthy Volunteers","status":"COMPLETED","sponsor":"AVIR Green Hills Biotechnology AG","startDate":"2007-03","conditions":"Seasonal Human Influenza","enrollment":48},{"nctId":"NCT00192218","phase":"PHASE4","title":"Study to Evaluate the Effectiveness of FluMist Vaccination in a School-Based Intervention Program","status":"COMPLETED","sponsor":"MedImmune LLC","startDate":"2004-10","conditions":"Influenza","enrollment":3022},{"nctId":"NCT00488046","phase":"PHASE1","title":"Single Group Study of the Safety of and Immune Response to a Bird Flu Virus Vaccine (H5N1) in Healthy Adults","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2007-06","conditions":"Influenza, Virus Diseases","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intranasal Influenza Live Attenuated Vaccine","genericName":"Intranasal Influenza Live Attenuated Vaccine","companyName":"Jiangsu Province Centers for Disease Control and Prevention","companyId":"jiangsu-province-centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"This live attenuated influenza vaccine stimulates immune responses by delivering weakened influenza virus strains intranasally to induce mucosal and systemic immunity. Used for Influenza prevention in children and adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}