{"id":"intranasal-capsaicin","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation / burning"},{"rate":null,"effect":"Rhinorrhea"},{"rate":null,"effect":"Sneezing"},{"rate":null,"effect":"Transient headache exacerbation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Capsaicin is a natural compound that binds to and activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory nerve endings. Upon initial activation, it causes release of neuropeptides like substance P and CGRP, but with repeated or sustained exposure, it leads to desensitization of these nociceptors. This desensitization reduces pain signaling and neurogenic inflammatory responses in the nasal cavity.","oneSentence":"Intranasal capsaicin activates TRPV1 nociceptors in the nasal mucosa to desensitize pain-sensing nerve fibers and reduce neurogenic inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:41.013Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cluster headache"},{"name":"Rhinitis / Nasal pain conditions"}]},"trialDetails":[{"nctId":"NCT03511846","phase":"PHASE1","title":"Pain Biomarker Study","status":"ENROLLING_BY_INVITATION","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-03-21","conditions":"Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia","enrollment":371},{"nctId":"NCT05093478","phase":"PHASE3","title":"The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2019-09-10","conditions":"Non-allergic Rhinitis","enrollment":28},{"nctId":"NCT03952845","phase":"NA","title":"Intranasal Capsaicinoid Spray","status":"NOT_YET_RECRUITING","sponsor":"Nova Scotia Health Authority","startDate":"2025-08-01","conditions":"Tolerance, Capsaicin, Rhinitis","enrollment":30},{"nctId":"NCT02493257","phase":"PHASE2","title":"Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2014-10","conditions":"Nonallergic Irritant Rhinitis","enrollment":22},{"nctId":"NCT00731250","phase":"PHASE1","title":"A Study To Assess The Effect Of SB-705498 In A Capsaicin Challenge Model","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-07-22","conditions":"Rhinitis","enrollment":45},{"nctId":"NCT01439308","phase":"PHASE2","title":"Intranasal SB-705498 in Non-allergic Rhinitis Patients","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-12","conditions":"Rhinitis","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":33,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intranasal capsaicin","genericName":"Intranasal capsaicin","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intranasal capsaicin activates TRPV1 nociceptors in the nasal mucosa to desensitize pain-sensing nerve fibers and reduce neurogenic inflammation. Used for Cluster headache, Rhinitis / Nasal pain conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}