{"id":"intramuscularly-administered-ad5-ncov-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL2108573","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The Ad5-nCoV vaccine uses a replication-incompetent adenovirus serotype 5 as a viral vector to transport genetic material encoding the SARS-CoV-2 spike protein into host cells. Once inside cells, the spike protein is expressed and presented to the immune system, triggering both CD8+ T-cell and antibody responses. This approach provides protection against SARS-CoV-2 infection and COVID-19 disease.","oneSentence":"An adenovirus type 5 (Ad5) vector vaccine delivers the SARS-CoV-2 spike protein gene intramuscularly to stimulate cellular and humoral immune responses against COVID-19.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:38.186Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"COVID-19 prevention in adults"}]},"trialDetails":[{"nctId":"NCT05855408","phase":"PHASE4","title":"Effectiveness of a Second COVID-19 Vaccine Booster in Chinese Adults","status":"UNKNOWN","sponsor":"Jiangsu Province Centers for Disease Control and Prevention","startDate":"2023-05-18","conditions":"COVID-19","enrollment":10000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intramuscularly administered Ad5-nCoV vaccine","genericName":"Intramuscularly administered Ad5-nCoV vaccine","companyName":"Jiangsu Province Centers for Disease Control and Prevention","companyId":"jiangsu-province-centers-for-disease-control-and-prevention","modality":"Biologic","firstApprovalDate":"","aiSummary":"An adenovirus type 5 (Ad5) vector vaccine delivers the SARS-CoV-2 spike protein gene intramuscularly to stimulate cellular and humoral immune responses against COVID-19. Used for COVID-19 prevention.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}