{"id":"intramuscular-depot-medroxyprogesterone-acetate","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Irregular bleeding or amenorrhea"},{"rate":"10-20","effect":"Weight gain"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5","effect":"Mood changes"},{"rate":null,"effect":"Delayed return to fertility"}]},"_chembl":{"chemblId":"CHEMBL287148","moleculeType":"Small molecule","molecularWeight":"386.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a progestin, medroxyprogesterone acetate acts on progesterone receptors in the hypothalamus and pituitary to suppress GnRH secretion, which prevents the luteinizing hormone (LH) surge necessary for ovulation. The intramuscular depot formulation provides sustained release over 12 weeks, maintaining contraceptive efficacy through both ovulation suppression and cervical mucus thickening.","oneSentence":"Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH) and inhibits ovulation, providing long-acting contraception.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:33.582Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception (prevention of pregnancy)"},{"name":"Management of endometriosis-related pain"}]},"trialDetails":[{"nctId":"NCT06665997","phase":"PHASE4","title":"Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2025-06-26","conditions":"Sickle Cell Disease (SCD), Vaso-Occlusive Pain Episode in Sickle Cell Disease","enrollment":65},{"nctId":"NCT05505435","phase":"PHASE4","title":"Continuation of Subcutaneous and Intramuscular Depot Medroxyprogesterone Acetate in Post-abortion Patients","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2022-08-01","conditions":"Contraception","enrollment":263},{"nctId":"NCT03660046","phase":"","title":"Contraceptive Hormones, Immunity, and Microbiome Evaluation","status":"COMPLETED","sponsor":"Emory University","startDate":"2018-12-07","conditions":"Hormonal Contraception","enrollment":155},{"nctId":"NCT03844633","phase":"PHASE4","title":"Postpartum Family Planning","status":"TERMINATED","sponsor":"Ohio State University","startDate":"2019-03-21","conditions":"Delay in Time to Lactogenesis Stage II","enrollment":49},{"nctId":"NCT04710017","phase":"NA","title":"Tranexamic Acid and Depot-Medroxyprogesterone Acetate for Perimenopausal Irregular Uterine Bleeding","status":"COMPLETED","sponsor":"Assiut University","startDate":"2021-02-01","conditions":"Uterine Bleeding","enrollment":110},{"nctId":"NCT02122198","phase":"NA","title":"Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2014-09-08","conditions":"Cognitive Impairment, Executive Dysfunction, Endothelial Dysfunction","enrollment":17},{"nctId":"NCT01873170","phase":"","title":"Quantification of Immune Cells in Women Using Contraception (CHIC II)","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2013-08","conditions":"HIV, Immune Cells (Mucosal and Systemic), Contraception","enrollment":326},{"nctId":"NCT00563576","phase":"NA","title":"Pilot Study of Femring Estrogen Supplementation During Depo-Provera Initiation","status":"COMPLETED","sponsor":"Columbia University","startDate":"2007-09","conditions":"Metrorrhagia","enrollment":71},{"nctId":"NCT03255941","phase":"EARLY_PHASE1","title":"Clinical Study of Depo Provera Comparing Lay Health Workers and Clinically-trained Health Workers","status":"COMPLETED","sponsor":"FHI 360","startDate":"2018-03-19","conditions":"Contraception","enrollment":460},{"nctId":"NCT03197961","phase":"EARLY_PHASE1","title":"Pharmacokinetics and Pharmacodynamics of DMPA With HIV PrEP","status":"COMPLETED","sponsor":"Sharon Achilles","startDate":"2017-11-17","conditions":"HIV/AIDS, Contraception","enrollment":15},{"nctId":"NCT02357368","phase":"PHASE4","title":"Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk","status":"COMPLETED","sponsor":"Lisa Haddad","startDate":"2015-02","conditions":"HIV, Contraception","enrollment":59},{"nctId":"NCT03395756","phase":"EARLY_PHASE1","title":"Depot Medroxyprogesterone Acetate as Emergency Contraception","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2018-08-31","conditions":"Emergency Contraception, Contraception","enrollment":30},{"nctId":"NCT02550067","phase":"NA","title":"The Evidence for Contraceptive Options and HIV Outcomes Trial","status":"COMPLETED","sponsor":"FHI 360","startDate":"2015-12-14","conditions":"HIV, Contraception","enrollment":7830},{"nctId":"NCT02412436","phase":"PHASE2","title":"PK Study of Rifampicin Interactions With DMPA and Efavirenz in TB","status":"COMPLETED","sponsor":"Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections","startDate":"2015-11-03","conditions":"HIV-1 Infection, Tuberculosis","enrollment":62},{"nctId":"NCT02456584","phase":"PHASE1","title":"Pharmacodynamics and Pharmacokinetics Study of Existing DMPA Contraceptive Methods","status":"COMPLETED","sponsor":"FHI 360","startDate":"2015-09","conditions":"Contraception","enrollment":42},{"nctId":"NCT02293694","phase":"NA","title":"Sayana® Press Self-injection Study in Malawi","status":"COMPLETED","sponsor":"FHI 360","startDate":"2015-09-17","conditions":"Contraception","enrollment":735},{"nctId":"NCT00828542","phase":"NA","title":"Safety of the Etonogestrel-releasing Implant During the Puerperium of Healthy Women","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2007-07","conditions":"Breastfeeding, Contraception","enrollment":40},{"nctId":"NCT02144259","phase":"NA","title":"The Impact of Contraception on Postpartum Weight Loss","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2011-04","conditions":"Weight","enrollment":100},{"nctId":"NCT02335203","phase":"PHASE2","title":"The Effect of Neoadjuvant DMPA on Glandular Cellularity in Women Awaiting Hysterectomy","status":"UNKNOWN","sponsor":"Women and Infants Hospital of Rhode Island","startDate":"2015-02","conditions":"Grade 1 Endometrial Endometrioid Adenocarcinoma, Grade 2 Endometrial Endometrioid Adenocarcinoma, Complex Atypical Endometrial Hyperplasia","enrollment":76},{"nctId":"NCT02894151","phase":"PHASE2","title":"Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2015-04","conditions":"Clinically Diagnosed Endometriotic Patient Was Defined as a Woman Who Has Pelvic Pain and at Least One Evidence of PV or TVS","enrollment":50},{"nctId":"NCT01056042","phase":"PHASE4","title":"Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain","status":"COMPLETED","sponsor":"Prince of Songkla University","startDate":"2007-06","conditions":"Endometriosis","enrollment":112},{"nctId":"NCT01791413","phase":"PHASE1, PHASE2","title":"Effect of Pre-operative Depo Medroxyprogesterone Acetate on Serum Anti-mullerian Hormone Level After Laparoscopic Ovarian Cystectomy of Endometriomas","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2012-03","conditions":"Endometriosis","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":45,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Depo Provera"],"phase":"marketed","status":"active","brandName":"intramuscular depot medroxyprogesterone acetate","genericName":"intramuscular depot medroxyprogesterone acetate","companyName":"Prince of Songkla University","companyId":"prince-of-songkla-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Medroxyprogesterone acetate is a synthetic progestin that suppresses gonadotropin-releasing hormone (GnRH) and inhibits ovulation, providing long-acting contraception. Used for Contraception (prevention of pregnancy), Management of endometriosis-related pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}