{"id":"intragastric-quinine-hydrochloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Cinchonism (tinnitus, hearing loss, visual disturbances)"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Thrombocytopenia"}]},"_chembl":{"chemblId":"CHEMBL588046","moleculeType":"Small molecule","molecularWeight":"360.89"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Quinine works by decreasing the excitability of muscle fibers and reducing the force of muscle contraction. When administered intragastrically, it is absorbed and distributed systemically to target skeletal muscle, where it suppresses spontaneous and evoked electrical activity. This mechanism makes it effective for symptomatic relief of nocturnal leg cramps, though the exact site and mode of action remain incompletely understood.","oneSentence":"Quinine hydrochloride acts as a cinchona alkaloid that reduces muscle excitability and contractility, primarily used to treat nocturnal leg cramps through local gastric delivery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:29.816Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nocturnal leg cramps"}]},"trialDetails":[{"nctId":"NCT02902198","phase":"NA","title":"Taste Physiology in Obese Volunteers Before and After Bariatric Surgery","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2014-12","conditions":"Obesity","enrollment":16},{"nctId":"NCT05720390","phase":"NA","title":"Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic Control","status":"COMPLETED","sponsor":"University of Adelaide","startDate":"2023-02-02","conditions":"Healthy","enrollment":15},{"nctId":"NCT05682339","phase":"NA","title":"Effects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic Control","status":"COMPLETED","sponsor":"University of Adelaide","startDate":"2023-06-19","conditions":"Healthy","enrollment":15},{"nctId":"NCT03565133","phase":"NA","title":"Quinine and Food Intake","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2018-08-17","conditions":"Obesity","enrollment":42},{"nctId":"NCT03985865","phase":"PHASE4","title":"IG vs ID Bitter Administration","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2017-03-02","conditions":"Obesity","enrollment":14},{"nctId":"NCT02946970","phase":"NA","title":"Brain Responses to Intragastric Administration of a Bitter Agonist in Homeostatic and Hedonic Brain Regions","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2015-09","conditions":"Healthy","enrollment":15},{"nctId":"NCT02759926","phase":"NA","title":"The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake","status":"UNKNOWN","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2011-08","conditions":"Healthy, Obesity","enrollment":98},{"nctId":"NCT02255812","phase":"NA","title":"Taste Physiology in Healthy, Normal-weight Volunteers","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2013-03","conditions":"Exploratory Behavior","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IG QHCl"],"phase":"marketed","status":"active","brandName":"Intragastric quinine hydrochloride","genericName":"Intragastric quinine hydrochloride","companyName":"Universitaire Ziekenhuizen KU Leuven","companyId":"universitaire-ziekenhuizen-ku-leuven","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Quinine hydrochloride acts as a cinchona alkaloid that reduces muscle excitability and contractility, primarily used to treat nocturnal leg cramps through local gastric delivery. Used for Nocturnal leg cramps.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}