{"id":"intragastric-denatonium-benzoate","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Gastrointestinal discomfort"},{"rate":null,"effect":"Taste aversion"}]},"_chembl":{"chemblId":"CHEMBL1738972","moleculeType":"Small molecule","molecularWeight":"325.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Denatonium benzoate is one of the most bitter substances known and activates bitter taste receptors (T2Rs) on the tongue and in the gastrointestinal tract. When administered intragastrically, it elicits a strong aversive gustatory response that can be used as a safety measure in pharmaceutical formulations or as a potential appetite-suppressing agent. The mechanism relies on the natural human rejection response to intensely bitter stimuli.","oneSentence":"Denatonium benzoate is a bitter-tasting compound administered intragastrically that triggers aversive taste responses to discourage accidental ingestion or promote satiety.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:49:28.743Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Appetite suppression / weight management (investigational)"},{"name":"Safety additive in pharmaceutical formulations to prevent accidental ingestion"}]},"trialDetails":[{"nctId":"NCT03985865","phase":"PHASE4","title":"IG vs ID Bitter Administration","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2017-03-02","conditions":"Obesity","enrollment":14},{"nctId":"NCT03777787","phase":"NA","title":"Bitter Tastants and Reflux","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2019-01-14","conditions":"Gastro Esophageal Reflux","enrollment":20},{"nctId":"NCT02759926","phase":"NA","title":"The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake","status":"UNKNOWN","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2011-08","conditions":"Healthy, Obesity","enrollment":98}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IG DB"],"phase":"marketed","status":"active","brandName":"Intragastric denatonium benzoate","genericName":"Intragastric denatonium benzoate","companyName":"Universitaire Ziekenhuizen KU Leuven","companyId":"universitaire-ziekenhuizen-ku-leuven","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Denatonium benzoate is a bitter-tasting compound administered intragastrically that triggers aversive taste responses to discourage accidental ingestion or promote satiety. Used for Appetite suppression / weight management (investigational), Safety additive in pharmaceutical formulations to prevent accidental ingestion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}