{"id":"intraarterial-alteplase","safety":{"commonSideEffects":[{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Bleeding (systemic)"},{"rate":null,"effect":"Reperfusion injury"},{"rate":null,"effect":"Angioedema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alteplase is a recombinant tissue plasminogen activator that directly activates the fibrinolytic cascade. When administered intraarterially, it achieves high local concentrations at the thrombus site, enabling rapid clot dissolution. This approach is particularly useful in acute ischemic stroke where direct delivery to the cerebral vasculature can restore blood flow to ischemic brain tissue.","oneSentence":"Intraarterial alteplase is a tissue plasminogen activator (tPA) that dissolves blood clots by converting plasminogen to plasmin, which breaks down fibrin in thrombi.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:43.614Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke (intraarterial administration)"},{"name":"Acute arterial thrombosis"}]},"trialDetails":[{"nctId":"NCT07471282","phase":"PHASE3","title":"Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy","status":"NOT_YET_RECRUITING","sponsor":"Chuansheng Zhao","startDate":"2026-03-01","conditions":"Stroke","enrollment":344},{"nctId":"NCT05499832","phase":"PHASE3","title":"Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2023-03-21","conditions":"Ischemic Stroke","enrollment":156},{"nctId":"NCT07302854","phase":"PHASE2, PHASE3","title":"Intra-arterial Recombinant Human Tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Medium Vessel Occlusion","status":"RECRUITING","sponsor":"Xiang Luo","startDate":"2025-12-30","conditions":"Acute Ischemic Stroke, Medium Vessel Occlusion","enrollment":382},{"nctId":"NCT06949228","phase":"PHASE2, PHASE3","title":"Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial","status":"RECRUITING","sponsor":"ProMedica Health System","startDate":"2025-07-30","conditions":"Ischemic Stroke, Acute Disease","enrollment":132},{"nctId":"NCT06210633","phase":"","title":"Prospective Registry of Endovascular Thrombectomy for eXtra-Large Ischemic Stroke","status":"RECRUITING","sponsor":"Zhongming Qiu","startDate":"2024-01-20","conditions":"Acute Ischemic Stroke (AIS), Acute Ischemic Stroke From Large Vessel Occlusion","enrollment":1000},{"nctId":"NCT04434768","phase":"PHASE1","title":"Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Ischemic Stroke","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ever Supreme Bio Technology Co., Ltd.","startDate":"2020-12-02","conditions":"Acute Stroke","enrollment":10},{"nctId":"NCT06221371","phase":"PHASE3","title":"Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2024-01-25","conditions":"Ischemic Stroke, Acute, Thrombolysis, Endovascular Treatment","enrollment":391},{"nctId":"NCT05631847","phase":"NA","title":"Direct Endovascular Treatment Versus Bridging Treatment In Basilar Artery Occlusive Stroke","status":"COMPLETED","sponsor":"Sichuan Academy of Medical Sciences","startDate":"2023-04-17","conditions":"Acute Ischemic Stroke, Basilar Artery Occlusion, Thrombosis","enrollment":345},{"nctId":"NCT07227740","phase":"","title":"Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury","status":"RECRUITING","sponsor":"Craig Hospital","startDate":"2025-07-15","conditions":"Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency","enrollment":48},{"nctId":"NCT05797792","phase":"PHASE3","title":"CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Clinic of Barcelona","startDate":"2023-11-18","conditions":"Stroke, Acute Ischemic, Stroke, Acute","enrollment":440},{"nctId":"NCT05897554","phase":"NA","title":"Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)","status":"COMPLETED","sponsor":"Xuanwu Hospital, Beijing","startDate":"2023-08-11","conditions":"Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction","enrollment":247},{"nctId":"NCT05657457","phase":"PHASE3","title":"Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)","status":"TERMINATED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2023-03-21","conditions":"Stroke, Ischemic","enrollment":145},{"nctId":"NCT05657470","phase":"PHASE2, PHASE3","title":"Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK)","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2023-03-21","conditions":"Stroke, Ischemic","enrollment":80},{"nctId":"NCT06101667","phase":"NA","title":"Efficacy and Safety of Endovascular Recanalization for Acute Basilar Artery Occlusion With Extended Time Window (ANGEL-BAO)","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2023-10-15","conditions":"Acute Ischemic Stroke, Basilar Artery Occlusion","enrollment":224},{"nctId":"NCT06768138","phase":"PHASE3","title":"Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke","status":"RECRUITING","sponsor":"Central Hospital, Nancy, France","startDate":"2025-06-01","conditions":"Stroke, Acute Ischemic","enrollment":626},{"nctId":"NCT04733742","phase":"PHASE2, PHASE3","title":"Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke","status":"COMPLETED","sponsor":"Xinqiao Hospital of Chongqing","startDate":"2022-05-09","conditions":"Stroke, Acute, Stroke, Ischemic","enrollment":550},{"nctId":"NCT05657444","phase":"PHASE3","title":"Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II)","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2023-03-21","conditions":"Stroke, Ischemic","enrollment":380},{"nctId":"NCT06760195","phase":"EARLY_PHASE1","title":"Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Capital Medical University","startDate":"2025-01-10","conditions":"Acute Ischemic Stroke","enrollment":6},{"nctId":"NCT02157532","phase":"NA","title":"Endovascular Acute Stroke Intervention Trial - the EASI Trial","status":"SUSPENDED","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2013-01","conditions":"Stroke, Acute","enrollment":480},{"nctId":"NCT05856851","phase":"PHASE3","title":"Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy","status":"RECRUITING","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2023-08-01","conditions":"Stroke, Acute Ischemic","enrollment":324},{"nctId":"NCT06034847","phase":"NA","title":"Treatment of Persistent Distal Occlusion After Successful Proximal Recanalization in Thrombectomy","status":"NOT_YET_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2024-09","conditions":"Stroke, Acute Thrombotic","enrollment":300},{"nctId":"NCT05735301","phase":"NA","title":"Patient Selection Using MR With Non-Perfusion Imaging for Endovascular Treatment Within 6 to 24 Hours","status":"RECRUITING","sponsor":"Tianjin Huanhu Hospital","startDate":"2019-01-01","conditions":"Endovascular Thrombectomy","enrollment":352},{"nctId":"NCT01096693","phase":"NA","title":"Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 2)","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2010-08","conditions":"Vascular Disease, Heart Disease","enrollment":12},{"nctId":"NCT05684172","phase":"PHASE2, PHASE3","title":"Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation","status":"COMPLETED","sponsor":"The First Affiliated Hospital of University of Science and Technology of China","startDate":"2023-01-24","conditions":"Acute Ischemic Stroke, Intracranial Artery Occlusion, Endovascular Thrombectomy","enrollment":208},{"nctId":"NCT05624190","phase":"PHASE4","title":"Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2023-02-16","conditions":"Ischemic Stroke, Acute","enrollment":256},{"nctId":"NCT05739487","phase":"","title":"Changes of Visual Field Defects After IAT for CRAO","status":"COMPLETED","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2020-07-01","conditions":"Central Retinal Artery Occlusion, Visual Field, Intra-arterial Thrombolysis","enrollment":27},{"nctId":"NCT05580822","phase":"PHASE2","title":"Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion","status":"UNKNOWN","sponsor":"First Hospital of China Medical University","startDate":"2023-01-01","conditions":"Basilar Artery Occlusion, Thrombectomy, Tenecteplase","enrollment":520},{"nctId":"NCT05562284","phase":"NA","title":"Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion","status":"UNKNOWN","sponsor":"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2022-06-01","conditions":"Central Retinal Artery Occlusion","enrollment":128},{"nctId":"NCT04751708","phase":"NA","title":"Endovascular Treatment for Acute Basilar Artery Occlusion","status":"COMPLETED","sponsor":"The First Affiliated Hospital of University of Science and Technology of China","startDate":"2021-02-21","conditions":"Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion","enrollment":340},{"nctId":"NCT03876119","phase":"PHASE2, PHASE3","title":"Intraarterial Alteplase Versus Placebo After Mechanical Thrombectomy","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2018-12-05","conditions":"Stroke, Acute","enrollment":121},{"nctId":"NCT04095767","phase":"NA","title":"Assessing Safety and Performance of the ANA Catheter System, Combined With a Stent Retriever in Acute Ischemic Stroke","status":"TERMINATED","sponsor":"Anaconda Biomed S.L.","startDate":"2019-09-21","conditions":"Stroke, Ischemic","enrollment":74},{"nctId":"NCT03340493","phase":"PHASE2","title":"Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)","status":"COMPLETED","sponsor":"Neuroscience Trials Australia","startDate":"2017-12-06","conditions":"Ischemic Stroke","enrollment":300},{"nctId":"NCT02618031","phase":"PHASE1","title":"The Capillary Index Score Trial","status":"COMPLETED","sponsor":"Firas Al-Ali","startDate":"2016-03-01","conditions":"Acute Stroke, Brain Ischemia, Ischemic Stroke","enrollment":57},{"nctId":"NCT03469206","phase":"NA","title":"Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals","status":"COMPLETED","sponsor":"Changhai Hospital","startDate":"2018-02-21","conditions":"Ischemic Stroke, Large Vessel Occlusion, Thrombectomy","enrollment":656},{"nctId":"NCT01581411","phase":"PHASE1","title":"Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2012-01","conditions":"Central Retinal Vein Occlusion","enrollment":1},{"nctId":"NCT02388061","phase":"PHASE2","title":"Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke","status":"COMPLETED","sponsor":"Neuroscience Trials Australia","startDate":"2015-03-23","conditions":"Ischemic Stroke","enrollment":202},{"nctId":"NCT01717755","phase":"NA","title":"Basilar Artery International Cooperation Study","status":"UNKNOWN","sponsor":"Erik van der Hoeven","startDate":"2011-10","conditions":"Basilar Artery Thrombosis, Basilar Artery Embolism, Stroke of Basilar Artery","enrollment":282},{"nctId":"NCT02216565","phase":"NA","title":"Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase","status":"TERMINATED","sponsor":"Fondation Ophtalmologique Adolphe de Rothschild","startDate":"2014-12-01","conditions":"Stroke, Acute","enrollment":2},{"nctId":"NCT02437409","phase":"","title":"Acute Recanalization of Thrombo-Embolic Ischemic Stroke With pREset (ARTESp)","status":"COMPLETED","sponsor":"Phenox GmbH","startDate":"2013-02","conditions":"Stroke","enrollment":115},{"nctId":"NCT01062698","phase":"NA","title":"Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy in Acute Ischemic Stroke","status":"TERMINATED","sponsor":"Central Hospital, Nancy, France","startDate":"2010-06","conditions":"Cerebral Stroke, Cerebrovascular Accident","enrollment":412},{"nctId":"NCT02448069","phase":"PHASE2","title":"Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2015-05","conditions":"Stroke, Cerebral Ischemia","enrollment":10},{"nctId":"NCT01413542","phase":"NA","title":"Pharmacogenetics of Ace Inhibitor-Associated Angioedema","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2011-11","conditions":"Hypertension, Diabetes Type 2","enrollment":44},{"nctId":"NCT01133223","phase":"PHASE2","title":"Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke","status":"WITHDRAWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2010-05","conditions":"Stroke","enrollment":""},{"nctId":"NCT01492725","phase":"PHASE2","title":"Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial","status":"TERMINATED","sponsor":"Neuroscience Trials Australia","startDate":"2012-06","conditions":"Ischemic Stroke","enrollment":70},{"nctId":"NCT00640367","phase":"PHASE3","title":"Intra-arterial Versus Systemic Thrombolysis for Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Niguarda Hospital","startDate":"2008-02","conditions":"Stroke, Cerebrovascular Accident","enrollment":350},{"nctId":"NCT00359424","phase":"PHASE3","title":"Interventional Management of Stroke (IMS) III Trial","status":"TERMINATED","sponsor":"Joseph Broderick","startDate":"2006-08","conditions":"Stroke","enrollment":656},{"nctId":"NCT01599728","phase":"NA","title":"Effect of Urocortins in Patients With Heart Failure","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2012-05","conditions":"Heart Failure, Endothelium","enrollment":22},{"nctId":"NCT00685945","phase":"NA","title":"Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2007-12","conditions":"Obesity","enrollment":24},{"nctId":"NCT00540527","phase":"PHASE3","title":"Local Versus Systemic Thrombolysis for Acute Ischemic Stroke (SYNTHESIS)","status":"COMPLETED","sponsor":"Niguarda Hospital","startDate":"2004-01","conditions":"Stroke, Cerebrovascular Accident","enrollment":54},{"nctId":"NCT01096706","phase":"NA","title":"Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)","status":"COMPLETED","sponsor":"University of Edinburgh","startDate":"2011-07","conditions":"Vascular Disease, Heart Disease","enrollment":10},{"nctId":"NCT01455935","phase":"PHASE2","title":"Wake up Symptomatic Stroke - Benefit of Intravenous Clot Busters or Endovascular Intervention","status":"UNKNOWN","sponsor":"Jacobs Neurological Institute","startDate":"2011-11","conditions":"Stroke","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":177,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Intraarterial alteplase recombinant tissue plasminogen activator (rTPA)","Intraarterial recombinant tissue plasminogen activator (rt-PA)"],"phase":"phase_3","status":"active","brandName":"Intraarterial alteplase","genericName":"Intraarterial alteplase","companyName":"Hospital Clinic of Barcelona","companyId":"hospital-clinic-of-barcelona","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intraarterial alteplase is a tissue plasminogen activator (tPA) that dissolves blood clots by converting plasminogen to plasmin, which breaks down fibrin in thrombi. Used for Acute ischemic stroke (intraarterial administration), Acute arterial thrombosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}