{"id":"intra-rectal-botulinum-toxin-injections","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Anal pain"},{"rate":"5-10%","effect":"Fecal urgency"},{"rate":"5-10%","effect":"Rectal bleeding"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved through the cleavage of SNARE proteins by botulinum toxin, preventing the fusion of vesicles containing acetylcholine with the presynaptic membrane. As a result, acetylcholine is not released into the synaptic cleft, and muscle contraction is inhibited. This mechanism is particularly useful for treating conditions characterized by excessive muscle contraction or spasm.","oneSentence":"Botulinum toxin injections work by blocking the release of acetylcholine at the neuromuscular junction, leading to muscle relaxation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:16:37.111Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fecal incontinence"},{"name":"Chronic anal fissure"}]},"trialDetails":[{"nctId":"NCT05998187","phase":"PHASE3","title":"Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections","status":"RECRUITING","sponsor":"University Hospital, Rouen","startDate":"2025-04-15","conditions":"Fecal Incontinence","enrollment":21},{"nctId":"NCT06785844","phase":"EARLY_PHASE1","title":"Intra-rectal Botulinum Toxin Injection for Intractable Non-retentive Fecal Incontinence in Children - an Open Label Pilot Study","status":"NOT_YET_RECRUITING","sponsor":"Shaare Zedek Medical Center","startDate":"2025-02-01","conditions":"Fecal Incontinence","enrollment":14},{"nctId":"NCT01589471","phase":"PHASE2","title":"The Value of Botox-A for Management of Low Anterior Resection Syndrome","status":"COMPLETED","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2012-05","conditions":"Low Anterior Resection Syndrome, Rectal Cancer","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"intra-rectal botulinum toxin injections","genericName":"intra-rectal botulinum toxin injections","companyName":"University Hospital, Rouen","companyId":"university-hospital-rouen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin injections work by blocking the release of acetylcholine at the neuromuscular junction, leading to muscle relaxation. Used for Fecal incontinence, Chronic anal fissure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}