{"id":"intra-arterial-tnk-and-albumin","safety":{"commonSideEffects":[{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Systemic bleeding"},{"rate":null,"effect":"Reperfusion injury"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TNK is a fibrin-specific thrombolytic agent that dissolves blood clots by converting plasminogen to plasmin. When administered intra-arterially with albumin as a carrier or adjuvant, this combination aims to achieve higher local drug concentrations at the site of arterial occlusion while potentially reducing systemic exposure and associated bleeding complications. Albumin may also provide neuroprotection and improve drug stability.","oneSentence":"Intra-arterial TNK (tenecteplase) and albumin work together to deliver thrombolytic therapy directly to occluded arteries while albumin may enhance drug delivery and reduce systemic toxicity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:48:39.015Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke (intra-arterial administration)"},{"name":"Acute arterial occlusion"}]},"trialDetails":[{"nctId":"NCT06113848","phase":"PHASE3","title":"Adjunctive Use of Intra-Arterial TNK and Albumin Following Thrombectomy","status":"UNKNOWN","sponsor":"Tianjin Huanhu Hospital","startDate":"2023-09-07","conditions":"Acute Ischemic Stroke","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intra-Arterial TNK and Albumin","genericName":"Intra-Arterial TNK and Albumin","companyName":"Tianjin Huanhu Hospital","companyId":"tianjin-huanhu-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intra-arterial TNK (tenecteplase) and albumin work together to deliver thrombolytic therapy directly to occluded arteries while albumin may enhance drug delivery and reduce systemic toxicity. Used for Acute ischemic stroke (intra-arterial administration), Acute arterial occlusion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}