{"id":"intra-arterial-tnk","safety":{"commonSideEffects":[{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Symptomatic intracerebral hemorrhage"},{"rate":null,"effect":"Reperfusion injury"},{"rate":null,"effect":"Systemic bleeding"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TNK is a genetically engineered variant of tissue plasminogen activator (tPA) with enhanced fibrin specificity and longer half-life. When delivered intra-arterially, it directly activates the fibrinolytic cascade at the site of thrombosis, promoting rapid clot dissolution. This approach is used in acute ischemic stroke to restore blood flow to affected brain tissue.","oneSentence":"TNK (tenecteplase) is a fibrinolytic agent that dissolves blood clots by converting plasminogen to plasmin when administered directly into an artery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:38.997Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke (intra-arterial administration)"}]},"trialDetails":[{"nctId":"NCT07469293","phase":"PHASE3","title":"Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO)","status":"NOT_YET_RECRUITING","sponsor":"Southwest Hospital, China","startDate":"2026-03-25","conditions":"Acute Ischemic Stroke","enrollment":488},{"nctId":"NCT05499832","phase":"PHASE3","title":"Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial 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Medium-vessel-occlusion","enrollment":614},{"nctId":"NCT06221371","phase":"PHASE3","title":"Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2024-01-25","conditions":"Ischemic Stroke, Acute, Thrombolysis, Endovascular Treatment","enrollment":391},{"nctId":"NCT04201964","phase":"NA","title":"Improving Neuroprotective Strategy for Ischemic Stroke With Poor Recanalization After Thrombectomy by Intra-arterial TNK (INSIST-TNK)","status":"RECRUITING","sponsor":"Hui-Sheng Chen","startDate":"2019-12-15","conditions":"Ischemic Stroke","enrollment":30},{"nctId":"NCT05892510","phase":"PHASE2, PHASE3","title":"Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke","status":"RECRUITING","sponsor":"University of Melbourne","startDate":"2024-06-01","conditions":"Ischemic Stroke, Acute, Cerebrovascular Disorders, Brain Disorder","enrollment":462},{"nctId":"NCT05657457","phase":"PHASE3","title":"Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)","status":"TERMINATED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2023-03-21","conditions":"Stroke, Ischemic","enrollment":145},{"nctId":"NCT05657470","phase":"PHASE2, PHASE3","title":"Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK)","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2023-03-21","conditions":"Stroke, Ischemic","enrollment":80},{"nctId":"NCT04733742","phase":"PHASE2, PHASE3","title":"Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke","status":"COMPLETED","sponsor":"Xinqiao Hospital of Chongqing","startDate":"2022-05-09","conditions":"Stroke, Acute, Stroke, Ischemic","enrollment":550},{"nctId":"NCT05657444","phase":"PHASE3","title":"Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II)","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2023-03-21","conditions":"Stroke, Ischemic","enrollment":380},{"nctId":"NCT05684172","phase":"PHASE2, PHASE3","title":"Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation","status":"COMPLETED","sponsor":"The First Affiliated Hospital of University of Science and Technology of China","startDate":"2023-01-24","conditions":"Acute Ischemic Stroke, Intracranial Artery Occlusion, Endovascular Thrombectomy","enrollment":208},{"nctId":"NCT05624190","phase":"PHASE4","title":"Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular 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Used for Acute ischemic stroke (intra-arterial administration).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}